|
|
USP7 |
ubiquitin specific peptidase 7 |
- Ub-specific processing proteases
- Formation of TC-NER Pre-Incision Complex
- Transcription-Coupled Nucleotide Excision Repair (TC-NER)
- Dual incision in TC-NER
- Gap-filling DNA repair synthesis and ligation in TC-NER
- Regulation of TP53 Degradation
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Regulation of PTEN localization
|
|
|
|
|
ALYREF |
Aly/REF export factor |
- Transport of the SLBP independent Mature mRNA
- Transport of the SLBP Dependant Mature mRNA
- Transport of Mature mRNA Derived from an Intronless Transcript
- Transport of Mature mRNA derived from an Intron-Containing Transcript
- mRNA Splicing - Major Pathway
- mRNA 3'-end processing
- RNA Polymerase II Transcription Termination
|
|
|
|
|
AR |
androgen receptor |
- HSP90 chaperone cycle for steroid hormone receptors (SHR)
- Nuclear Receptor transcription pathway
- SUMOylation of intracellular receptors
- Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
- Ub-specific processing proteases
- RUNX2 regulates osteoblast differentiation
- RUNX2 regulates osteoblast differentiation
|
- Diethylstilbestrol
- Levonorgestrel
- Progesterone
- Spironolactone
- Flutamide
- Oxandrolone
- Fluphenazine
- Testosterone
- Mitotane
- Estrone
- Nilutamide
- Tamoxifen
- Norethisterone
- Drostanolone
- Norgestimate
- Nandrolone phenpropionate
- Ketoconazole
- Acetophenazine
- Bicalutamide
- Fluoxymesterone
- Drospirenone
- Danazol
- Testosterone propionate
- Oxybenzone
- 1-Testosterone
- Boldenone
- Calusterone
- Periciazine
- Prasterone
- Flufenamic acid
- Stanolone
- (R)-Bicalutamide
- Metribolone
- (3AALPHA,4ALPHA,7ALPHA,7AALPHA)- 3A,4,7,7A-TETRAHYDRO-2-(4-NITRO-1-NAPHTHALENYL)-4,7-ETHANO-1H-ISOINDOLE-1,3(2H)-DIONE
- Cyproterone acetate
- LGD2941
- Dimethylcurcumin
- Oxymetholone
- Methyltestosterone
- Norelgestromin
- Stanozolol
- Tetrahydrogestrinone
- (2S)-N-(4-cyano-3-iodophenyl)-3-(4-cyanophenoxy)-2-hydroxy-2-methylpropanamide
- BMS-564929
- S-23
- phenoxy)propyl]amino}-2-(trifluoromethyl)benzonitrile
- (2S)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]-3-(pentafluorophenoxy)propanamide
- Andarine
- (R)-3-BROMO-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- (5S,8R,9S,10S,13R,14S,17S)-13-{2-[(3,5-DIFLUOROBENZYL)OXY]ETHYL}-17-HYDROXY-10-METHYLHEXADECAHYDRO-3H-CYCLOPENTA[A]PHENANTHREN-3-ONE
- S-3-(4-FLUOROPHENOXY)-2-HYDROXY-2-METHYL-N-[4-NITRO-3-(TRIFLUOROMETHYL)PHENYL]PROPANAMIDE
- 1-TERT-BUTYL-3-(2,5-DIMETHYLBENZYL)-1H-PYRAZOLO[3,4-D]PYRIMIDIN-4-AMINE
- 4-[(7R,7AS)-7-HYDROXY-1,3-DIOXOTETRAHYDRO-1H-PYRROLO[1,2-C]IMIDAZOL-2(3H)-YL]-1-NAPHTHONITRILE
- 2-chloro-4-{[(1R,3Z,7S,7aS)-7-hydroxy-1-(trifluoromethyl)tetrahydro-1H-pyrrolo[1,2-c][1,3]oxazol-3-ylidene]amino}-3-methylbenzonitrile
- LGD-2226
- 3-[(4-AMINO-1-TERT-BUTYL-1H-PYRAZOLO[3,4-D]PYRIMIDIN-3-YL)METHYL]PHENOL
- Triclosan
- Nandrolone decanoate
- Ulipristal
- Enzalutamide
- Eugenol
- Dienogest
- Norethynodrel
- Norgestrel
- Homosalate
- Enzacamene
- Mibolerone
- Phenothiazine
- Gestrinone
- Apalutamide
- Clascoterone
- Darolutamide
- Esculin
- Ligandrol
- Testosterone cypionate
- Testosterone enanthate
- Testosterone undecanoate
- Stanolone acetate
- Segesterone acetate
- Boldenone undecylenate
- Echinacoside
- Ketodarolutamide
|
- 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
- 46,XY disorders of sex development (Other), including: Persistent Mullerian duct syndrome; Hypospadias; Cryptorchidism
- Prostate cancer
- Spinal and bulbar muscular atrophy (SBMA); Kennedy's disease
|
|
|
CCT3 |
chaperonin containing TCP1 subunit 3 |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
|
- Phosphoaminophosphonic Acid-Adenylate Ester
- Artenimol
|
|
|
|
CCT4 |
chaperonin containing TCP1 subunit 4 |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- BBSome-mediated cargo-targeting to cilium
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
|
|
|
|
|
EEF2 |
eukaryotic translation elongation factor 2 |
- Peptide chain elongation
- Peptide chain elongation
- Uptake and function of diphtheria toxin
- Synthesis of diphthamide-EEF2
- Synthesis of diphthamide-EEF2
- Neutrophil degranulation
- Protein methylation
|
- Adenosine-5-Diphosphoribose
- Diphthamide
- Guanosine-5'-Diphosphate
- N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE
- Esketamine
- Moxetumomab Pasudotox
|
|
|
|
HSP90B1 |
heat shock protein 90 beta family member 1 |
- Trafficking and processing of endosomal TLR
- Scavenging by Class A Receptors
- Scavenging by Class A Receptors
- ATF6 (ATF6-alpha) activates chaperone genes
- Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
- Interleukin-4 and Interleukin-13 signaling
- Post-translational protein phosphorylation
|
- Rifabutin
- 2-Chlorodideoxyadenosine
- Geldanamycin
- Diglyme
- N-Ethyl-5'-Carboxamido Adenosine
- Radicicol
- METHYL 3-CHLORO-2-{3-[(2,5-DIHYDROXY-4-METHOXYPHENYL)AMINO]-3-OXOPROPYL}-4,6-DIHYDROXYBENZOATE
- 2-(3-AMINO-2,5,6-TRIMETHOXYPHENYL)ETHYL 5-CHLORO-2,4-DIHYDROXYBENZOATE
- Copper
|
|
|
|
MYH10 |
myosin heavy chain 10 |
- EPHA-mediated growth cone collapse
- Sema4D induced cell migration and growth-cone collapse
- RHO GTPases activate PKNs
- RHO GTPases activate CIT
- RHO GTPases Activate ROCKs
- RHO GTPases activate PAKs
- RHO GTPases activate PAKs
|
|
|
|
|
RAD21 |
RAD21 cohesin complex component |
- Meiotic synapsis
- Separation of Sister Chromatids
- Establishment of Sister Chromatid Cohesion
- Cohesin Loading onto Chromatin
- Resolution of Sister Chromatid Cohesion
- SUMOylation of DNA damage response and repair proteins
- Estrogen-dependent gene expression
|
|
|
|
|
SMARCA4 |
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
- Interleukin-7 signaling
- Formation of the beta-catenin:TCF transactivating complex
- RMTs methylate histone arginines
- Chromatin modifying enzymes
- RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
|
|
|
|
|
STAG2 |
stromal antigen 2 |
- Meiotic synapsis
- Separation of Sister Chromatids
- Establishment of Sister Chromatid Cohesion
- Cohesin Loading onto Chromatin
- Resolution of Sister Chromatid Cohesion
- SUMOylation of DNA damage response and repair proteins
- Estrogen-dependent gene expression
|
|
|
|
|
STUB1 |
STIP1 homology and U-box containing protein 1 |
- Downregulation of TGF-beta receptor signaling
- RIPK1-mediated regulated necrosis
- Regulation of necroptotic cell death
- Downregulation of ERBB2 signaling
- Regulation of RUNX2 expression and activity
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
|
|
|
|
|
YAP1 |
Yes1 associated transcriptional regulator |
- Nuclear signaling by ERBB4
- Signaling by Hippo
- YAP1- and WWTR1 (TAZ)-stimulated gene expression
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
- RUNX2 regulates osteoblast differentiation
- RUNX3 regulates YAP1-mediated transcription
- EGR2 and SOX10-mediated initiation of Schwann cell myelination
|
|
|
|
|
CCT6A |
chaperonin containing TCP1 subunit 6A |
- Prefoldin mediated transfer of substrate to CCT/TriC
- Formation of tubulin folding intermediates by CCT/TriC
- Folding of actin by CCT/TriC
- Association of TriC/CCT with target proteins during biosynthesis
- Association of TriC/CCT with target proteins during biosynthesis
- Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
|
|
|
|
|
CFL1 |
cofilin 1 |
- Platelet degranulation
- Regulation of actin dynamics for phagocytic cup formation
- EPHB-mediated forward signaling
- Sema3A PAK dependent Axon repulsion
- RHO GTPases Activate ROCKs
- Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
|
- Dodecyldimethylamine N-oxide
- Copper
- Artenimol
|
|
|
|
DAXX |
death domain associated protein |
- SUMOylation of transcription cofactors
- Regulation of TP53 Degradation
- HCMV Early Events
- Inhibition of DNA recombination at telomere
- Defective Inhibition of DNA Recombination at Telomere Due to DAXX Mutations
- Defective Inhibition of DNA Recombination at Telomere Due to ATRX Mutations
|
|
|
|
|
EPHA2 |
EPH receptor A2 |
- EPH-Ephrin signaling
- EPH-Ephrin signaling
- EPHA-mediated growth cone collapse
- EPHA-mediated growth cone collapse
- EPH-ephrin mediated repulsion of cells
- EPH-ephrin mediated repulsion of cells
|
- Dasatinib
- Phosphoaminophosphonic Acid-Adenylate Ester
- Regorafenib
- Fostamatinib
|
|
|
|
EXOSC1 |
exosome component 1 |
- ATF4 activates genes in response to endoplasmic reticulum stress
- mRNA decay by 3' to 5' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
- Major pathway of rRNA processing in the nucleolus and cytosol
|
|
|
|
|
EXOSC2 |
exosome component 2 |
- ATF4 activates genes in response to endoplasmic reticulum stress
- mRNA decay by 3' to 5' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
- Major pathway of rRNA processing in the nucleolus and cytosol
|
|
|
|
|
EXOSC4 |
exosome component 4 |
- ATF4 activates genes in response to endoplasmic reticulum stress
- mRNA decay by 3' to 5' exoribonuclease
- Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA
- Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
- KSRP (KHSRP) binds and destabilizes mRNA
- Major pathway of rRNA processing in the nucleolus and cytosol
|
|
|