PTEN - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SLC25A13	solute carrier family 25 member 13	Mitochondrial protein import Gluconeogenesis Aspartate and asparagine metabolism	Aspartic acid	Citrullinemia (CTLN)
SLC25A3	solute carrier family 25 member 3
SLC25A5	solute carrier family 25 member 5	Vpr-mediated induction of apoptosis by mitochondrial outer membrane permeabilization Transport of nucleosides and free purine and pyrimidine bases across the plasma membrane	Clodronic acid Etidronic acid
SLC9A3R1	SLC9A3 regulator 1			Nephrolithiasis/osteoporosis, hypophosphatemic
SLC9A3R2	SLC9A3 regulator 2
SMARCA4	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4	Interleukin-7 signaling Formation of the beta-catenin:TCF transactivating complex RMTs methylate histone arginines Chromatin modifying enzymes RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known EGR2 and SOX10-mediated initiation of Schwann cell myelination EGR2 and SOX10-mediated initiation of Schwann cell myelination
SMARCA5	SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5	NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Deposition of new CENPA-containing nucleosomes at the centromere	Beta-D-Glucose 4-Deoxy-Alpha-D-Glucose
SMC2	structural maintenance of chromosomes 2	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
SMC4	structural maintenance of chromosomes 4	Condensation of Prophase Chromosomes Condensation of Prometaphase Chromosomes Condensation of Prometaphase Chromosomes
SMCHD1	structural maintenance of chromosomes flexible hinge domain containing 1
SNAI1	snail family transcriptional repressor 1	Regulation of PTEN gene transcription Regulation of PTEN gene transcription
SNRNP200	small nuclear ribonucleoprotein U5 subunit 200	mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway		Retinitis pigmentosa (RP)
SNRPA1	small nuclear ribonucleoprotein polypeptide A'	mRNA Splicing - Major Pathway Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
SNRPB2	small nuclear ribonucleoprotein polypeptide B2	mRNA Splicing - Major Pathway
SNRPD1	small nuclear ribonucleoprotein D1 polypeptide	snRNP Assembly mRNA Splicing - Major Pathway mRNA Splicing - Minor Pathway
SNTB2	syntrophin beta 2
SNX27	sorting nexin 27
SPTAN1	spectrin alpha, non-erythrocytic 1	Caspase-mediated cleavage of cytoskeletal proteins Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade Neutrophil degranulation COPI-mediated anterograde transport		Early infantile epileptic encephalopathy; Ohtahara syndrome
SPTBN1	spectrin beta, non-erythrocytic 1	Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Calcium 1D-myo-inositol 1,4,5-trisphosphate
SRP14	signal recognition particle 14	SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Neutrophil degranulation	Artenimol

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