MUC1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SLC22A1	solute carrier family 22 member 1	Neurotransmitter clearance Norepinephrine Neurotransmitter Release Cycle Abacavir transmembrane transport Na+/Cl- dependent neurotransmitter transporters Organic cation transport
AQP1	aquaporin 1 (Colton blood group)	Erythrocytes take up carbon dioxide and release oxygen Erythrocytes take up oxygen and release carbon dioxide Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Acetazolamide B-nonylglucoside Mersalyl
GALNT1	polypeptide N-acetylgalactosaminyltransferase 1	COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins Maturation of protein 3a Maturation of protein 3a
NEU1	neuraminidase 1	Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation	Oseltamivir	Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
SFTPC	surfactant protein C	Surfactant metabolism Defective pro-SFTPC causes SMDP2 and RDS Defective CSF2RB causes SMDP5 Defective CSF2RA causes SMDP4		Pulmonary surfactant metabolism dysfunction (SMDP)
ADIPOQ	adiponectin, C1Q and collagen domain containing	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation		Adiponectin deficiency
C2	complement C2	Initial triggering of complement Activation of C3 and C5 Regulation of Complement cascade		Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency Systemic lupus erythematosus
CTNND1	catenin delta 1	Adherens junctions interactions VEGFR2 mediated vascular permeability InlA-mediated entry of Listeria monocytogenes into host cells
GDNF	glial cell derived neurotrophic factor	NCAM1 interactions RAF/MAP kinase cascade RET signaling	Chondroitin sulfate	Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS)
AQP2	aquaporin 2	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins		Congenital nephrogenic diabetes insipidus (NDI)
AQP3	aquaporin 3 (Gill blood group)	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins	Sennosides
C1GALT1	core 1 synthase, glycoprotein-N-acetylgalactosamine 3-beta-galactosyltransferase 1	Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) O-linked glycosylation of mucins
CXCL16	C-X-C motif chemokine ligand 16	Chemokine receptors bind chemokines G alpha (i) signalling events
CXCL9	C-X-C motif chemokine ligand 9	Chemokine receptors bind chemokines G alpha (i) signalling events
GALNT12	polypeptide N-acetylgalactosaminyltransferase 12	Defective GALNT12 causes colorectal cancer 1 (CRCS1) O-linked glycosylation of mucins
GALNT2	polypeptide N-acetylgalactosaminyltransferase 2	COPI-independent Golgi-to-ER retrograde traffic O-linked glycosylation of mucins
GAST	gastrin	G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Oxetacaine
ICMT	isoprenylcysteine carboxyl methyltransferase	Gamma carboxylation, hypusine formation and arylsulfatase activation RAS processing
NDUFA3	NADH:ubiquinone oxidoreductase subunit A3	Respiratory electron transport Complex I biogenesis	NADH
PLN	phospholamban	Ion homeostasis Ion transport by P-type ATPases

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