MUC1 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CTNNB1	catenin beta 1	Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade TCF dependent signaling in response to WNT Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex LRR FLII-interacting protein 1 (LRRFIP1) activates type I IFN production Apoptotic cleavage of cell adhesion proteins Deactivation of the beta-catenin transactivating complex Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) Ca2+ pathway Adherens junctions interactions Binding of TCF/LEF:CTNNB1 to target gene promoters Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane VEGFR2 mediated vascular permeability Myogenesis Myogenesis Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated RHO GTPases activate IQGAPs Transcriptional Regulation by VENTX InlA-mediated entry of Listeria monocytogenes into host cells RUNX3 regulates WNT signaling	Urea	Gastric cancer Colorectal cancer Endometrial Cancer Pilomatricoma; Epithelioma calcificans of Malherbe Thyroid cancer Hepatocellular carcinoma
CYB5B	cytochrome b5 type B	Phase I - Functionalization of compounds	Phenethyl Isothiocyanate
ERBB3	erb-b2 receptor tyrosine kinase 3		Tucatinib	Lethal congenital contractural syndrome (LCCS) Type I diabetes mellitus
GAST	gastrin	G alpha (q) signalling events Gastrin-CREB signalling pathway via PKC and MAPK	Oxetacaine
GDNF	glial cell derived neurotrophic factor	NCAM1 interactions RAF/MAP kinase cascade RET signaling	Chondroitin sulfate	Hirschsprung disease (HD) Congenital central hypoventilation syndrome (CCHS)
HSPA4	heat shock protein family A (Hsp70) member 4	Regulation of HSF1-mediated heat shock response	Phenethyl Isothiocyanate
MIP	major intrinsic protein of lens fiber	Passive transport by Aquaporins	B-nonylglucoside
NDUFA3	NADH:ubiquinone oxidoreductase subunit A3	Respiratory electron transport Complex I biogenesis	NADH
NEU1	neuraminidase 1	Glycosphingolipid metabolism Sialic acid metabolism Defective NEU1 causes sialidosis Neutrophil degranulation	Oseltamivir	Sialidosis; Mucolipidosis I Galactosialidosis Progressive myoclonic epilepsy (PME), including: Lafora disease (LBD); Unverricht-Lundborg disease (ULD); Neuronal ceroid lipofuscinoses (NCL); Type I sialidosis; Action myoclonus-renal failure syndrome (AMRF); Type III Gaucher disease (GD)
ADAM33	ADAM metallopeptidase domain 33			Asthma
ADGRB3	adhesion G protein-coupled receptor B3
ADIPOQ	adiponectin, C1Q and collagen domain containing	AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation		Adiponectin deficiency
ANKRD46	ankyrin repeat domain 46
APC	APC regulator of WNT signaling pathway	Apoptotic cleavage of cellular proteins Degradation of beta-catenin by the destruction complex Beta-catenin phosphorylation cascade Deactivation of the beta-catenin transactivating complex Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane Signaling by GSK3beta mutants S33 mutants of beta-catenin aren't phosphorylated S37 mutants of beta-catenin aren't phosphorylated S45 mutants of beta-catenin aren't phosphorylated T41 mutants of beta-catenin aren't phosphorylated APC truncation mutants are not K63 polyubiquitinated APC truncation mutants have impaired AXIN binding AXIN missense mutants destabilize the destruction complex Truncations of AMER1 destabilize the destruction complex Ovarian tumor domain proteases		Familial adenomatous polyposis Esophageal cancer Gastric cancer Cancer of the anal canal Gallbladder cancer
AQP2	aquaporin 2	Vasopressin regulates renal water homeostasis via Aquaporins Passive transport by Aquaporins		Congenital nephrogenic diabetes insipidus (NDI)
ARV1	ARV1 homolog, fatty acid homeostasis modulator	Cholesterol biosynthesis
BMI1	BMI1 proto-oncogene, polycomb ring finger	Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6		Penile cancer
BRICD5	BRICHOS domain containing 5
BTN2A2	butyrophilin subfamily 2 member A2	Butyrophilin (BTN) family interactions
C14orf180	chromosome 14 open reading frame 180

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