MET - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Associated Diseases Hide
SHC1	SHC adaptor protein 1	Constitutive Signaling by Ligand-Responsive EGFR Cancer Variants SHC1 events in ERBB2 signaling SHC1 events in ERBB2 signaling SHC1 events in ERBB4 signaling Signalling to RAS Signalling to RAS SHC1 events in EGFR signaling Tie2 Signaling Integrin signaling XBP1(S) activates chaperone genes Interleukin-3, Interleukin-5 and GM-CSF signaling Constitutive Signaling by EGFRvIII RAF/MAP kinase cascade Signal attenuation Insulin receptor signalling cascade Insulin receptor signalling cascade RET signaling Interleukin-15 signaling Interleukin-15 signaling Interleukin-2 signaling Erythropoietin activates RAS Erythropoietin activates RAS Interleukin receptor SHC signaling Constitutive Signaling by Overexpressed ERBB2 Signaling by ERBB2 KD Mutants Signaling by ERBB2 ECD mutants Signaling by ERBB2 TMD/JMD mutants
SHC2	SHC adaptor protein 2	Signalling to RAS Signalling to RAS VEGFA-VEGFR2 Pathway RAF/MAP kinase cascade
SHC3	SHC adaptor protein 3	Signalling to RAS Signalling to RAS RAF/MAP kinase cascade RET signaling
SHC4	SHC adaptor protein 4
SHD	Src homology 2 domain containing transforming protein D
SLA2	Src like adaptor 2	Negative regulation of FLT3
SMC1A	structural maintenance of chromosomes 1A	Meiotic synapsis Separation of Sister Chromatids Establishment of Sister Chromatid Cohesion Cohesin Loading onto Chromatin Resolution of Sister Chromatid Cohesion SUMOylation of DNA damage response and repair proteins Estrogen-dependent gene expression	Cornelia de Lange syndrome (CdLS)
SNAPIN	SNAP associated protein	Golgi Associated Vesicle Biogenesis
SNX2	sorting nexin 2	Golgi Associated Vesicle Biogenesis
SOCS1	suppressor of cytokine signaling 1	Interleukin-7 signaling Regulation of KIT signaling MyD88:MAL(TIRAP) cascade initiated on plasma membrane Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
SOCS2	suppressor of cytokine signaling 2	Interleukin-7 signaling Neddylation Negative regulation of FLT3 Growth hormone receptor signaling
SOCS3	suppressor of cytokine signaling 3	Interleukin-6 signaling Signaling by Leptin Interleukin-4 and Interleukin-13 signaling Interferon gamma signaling Regulation of IFNG signaling PTK6 Activates STAT3 RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Neddylation Interferon alpha/beta signaling Regulation of IFNA signaling Growth hormone receptor signaling Antigen processing: Ubiquitination & Proteasome degradation
SOCS5	suppressor of cytokine signaling 5	Interleukin-4 and Interleukin-13 signaling Neddylation
SOCS6	suppressor of cytokine signaling 6	Regulation of KIT signaling Neddylation Negative regulation of FLT3
SPSB1	splA/ryanodine receptor domain and SOCS box containing 1	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
STAP1	signal transducing adaptor family member 1
STK11	serine/threonine kinase 11	AMPK inhibits chREBP transcriptional activation activity Energy dependent regulation of mTOR by LKB1-AMPK Regulation of TP53 Activity through Phosphorylation FOXO-mediated transcription of cell death genes	Peutz-Jeghers syndrome Pancreatic cancer
TNS1	tensin 1
TNS2	tensin 2
TNS3	tensin 3	MET interacts with TNS proteins

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