LYN - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
CD79A	CD79a molecule	CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers		Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
CD79B	CD79b molecule	CD22 mediated BCR regulation Antigen activates B Cell Receptor (BCR) leading to generation of second messengers Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Polatuzumab vedotin	Agammaglobulinemias, including the following six diseases: X-linked agammaglobulinemia (Bruton's agammaglobulinemia, XLA); IgM heavy chain gene deletions; Ig-alpha defect; Autosomal recessive agammaglobulinaemia; B cell-linker protein (BLNK) deficiency; Leucine-rich repeat-containing 8
FOLR1	folate receptor alpha	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport	Folic acid Vintafolide Farletuzumab
GP6	glycoprotein VI platelet	GPVI-mediated activation cascade Cell surface interactions at the vascular wall Platelet Adhesion to exposed collagen
NMT1	N-myristoyltransferase 1	Late Phase of HIV Life Cycle Inactivation, recovery and regulation of the phototransduction cascade Activation, myristolyation of BID and translocation to mitochondria	(1-Methyl-1h-Imidazol-2-Yl)-(3-Methyl-4-{3-[(Pyridin-3-Ylmethyl)-Amino]-Propoxy}-Benzofuran-2-Yl)-Methanone
PTK2B	protein tyrosine kinase 2 beta	Signal regulatory protein family interactions VEGFA-VEGFR2 Pathway Interleukin-2 signaling	Leflunomide Genistein 4-{[4-{[(1R,2R)-2-(dimethylamino)cyclopentyl]amino}-5-(trifluoromethyl)pyrimidin-2-yl]amino}-N-methylbenzenesulfonamide Baricitinib Fostamatinib
PTPRC	protein tyrosine phosphatase receptor type C	Phosphorylation of CD3 and TCR zeta chains Other semaphorin interactions Neutrophil degranulation		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
TRIM28	tripartite motif containing 28	Generic Transcription Pathway SUMOylation of transcription cofactors HCMV Early Events
ADAM15	ADAM metallopeptidase domain 15	Degradation of the extracellular matrix Invadopodia formation
CSF1R	colony stimulating factor 1 receptor	Other interleukin signaling Transcriptional Regulation by VENTX	Imatinib Sunitinib ABT-869 5-CYANO-FURAN-2-CARBOXYLIC ACID [5-HYDROXYMETHYL-2-(4-METHYL-PIPERIDIN-1-YL)-PHENYL]-AMIDE 6-CHLORO-3-(3-METHYLISOXAZOL-5-YL)-4-PHENYLQUINOLIN-2(1H)-ONE Fostamatinib Erdafitinib Pexidartinib	Choriocarcinoma
CSF3R	colony stimulating factor 3 receptor	Other interleukin signaling Transcriptional regulation of granulopoiesis	Pegfilgrastim Filgrastim FavId Lenograstim Lipegfilgrastim
CTLA4	cytotoxic T-lymphocyte associated protein 4	CTLA4 inhibitory signaling RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)	Ipilimumab Tremelimumab	Type I diabetes mellitus Graves' disease Allograft rejection Hashimoto's thyroiditis
DOK1	docking protein 1	PTK6 Regulates RTKs and Their Effectors AKT1 and DOK1 RET signaling
DOK2	docking protein 2	Tie2 Signaling RET signaling
MME	membrane metalloendopeptidase	Metabolism of Angiotensinogen to Angiotensins Neutrophil degranulation	Candoxatril Omapatrilat N-[3-[(1-Aminoethyl)(Hydroxy)Phosphoryl]-2-(1,1'-Biphenyl-4-Ylmethyl)Propanoyl]Alanine Phosphoramidon N-(3-Phenyl-2-Sulfanylpropanoyl)Phenylalanylalanine [2(R,S)-2-Sulfanylheptanoyl]-Phe-Ala Daglutril 2-[(1S)-1-BENZYL-2-SULFANYLETHYL]-1H-IMIDAZO[4,5-C]PYRIDIN-5-IUM Thiorphan Sacubitril Candoxatrilat
NPHS1	NPHS1 adhesion molecule, nephrin	Nephrin family interactions Nephrin family interactions		Nephrotic syndrome and focal segmental glomerulosclerosis
PAG1	phosphoprotein membrane anchor with glycosphingolipid microdomains 1	GAB1 signalosome Phosphorylation of CD3 and TCR zeta chains
PDE4A	phosphodiesterase 4A	DARPP-32 events G alpha (s) signalling events	Caffeine Theophylline Dyphylline Enprofylline Dipyridamole Iloprost Oxtriphylline Amrinone Roflumilast Piclamilast Crisaborole Ibudilast Propentofylline Drotaverine (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Tofisopam Trapidil
PDE4D	phosphodiesterase 4D	DARPP-32 events G alpha (s) signalling events	Adenosine phosphate Caffeine Caffeine Dyphylline Iloprost Amrinone Roflumilast Piclamilast Rolipram 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol Zardaverine 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester (S)-Rolipram Cilomilast (R)-Rolipram 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester Crisaborole Ibudilast Tetomilast Exisulind (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER 3-isobutyl-1-methyl-7H-xanthine 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid Trapidil
PPP1R15A	protein phosphatase 1 regulatory subunit 15A	Downregulation of TGF-beta receptor signaling Response of EIF2AK1 (HRI) to heme deficiency

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