Search Results for: HRAS

153 interactions involving HRAS - HRas proto-oncogene, GTPase found:

Sort by: Symbol Number of Pathways Number of Drugs Number of Diseases
Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
RALGDS ral guanine nucleotide dissociation stimulator
  • p38MAPK events
  • p38MAPK events
  • RAF/MAP kinase cascade
ARHGAP10 Rho GTPase activating protein 10
  • Rho GTPase cycle
  • Regulation of PAK-2p34 activity by PS-GAP/RHG10
FNTB farnesyltransferase, CAAX box, beta
  • Inactivation, recovery and regulation of the phototransduction cascade
  • RAS processing
  • AZD3409
  • Tipifarnib
  • Lonafarnib
  • 2-CHLORO-5-(3-CHLORO-PHENYL)-6-[(4-CYANO-PHENYL)-(3-METHYL-3H-IMIDAZOL-4-YL)- METHOXYMETHYL]-NICOTINONITRILE
  • (11S)-8-CHLORO-11-[1-(METHYLSULFONYL)PIPERIDIN-4-YL]-6-PIPERAZIN-1-YL-11H-BENZO[5,6]CYCLOHEPTA[1,2-B]PYRIDINE
  • L-778123
  • [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
  • Farnesyl diphosphate
  • Geranylgeranyl diphosphate
  • ALPHA-HYDROXYFARNESYLPHOSPHONIC ACID
  • (20S)-19,20,21,22-TETRAHYDRO-19-OXO-5H-18,20-ETHANO-12,14-ETHENO-6,10-METHENO-18H-BENZ[D]IMIDAZO[4,3-K][1,6,9,12]OXATRIAZA-CYCLOOCTADECOSINE-9-CARBONITRILE
  • (20S)-19,20,22,23-TETRAHYDRO-19-OXO-5H,21H-18,20-ETHANO-12,14-ETHENO-6,10-METHENOBENZ[D]IMIDAZO[4,3-L][1,6,9,13]OXATRIAZACYCLONOADECOSINE-9-CARBONITRILE
ICMT isoprenylcysteine carboxyl methyltransferase
  • Gamma carboxylation, hypusine formation and arylsulfatase activation
  • RAS processing
KRT17 keratin 17
  • Keratinization
  • Formation of the cornified envelope
  • Pachyonychia congenita, including: Jadassohn-Lewandowsky syndrome; Jackson-Lawler syndrome ; Steatocystoma multiplex
KRT18 keratin 18
  • Keratinization
  • Formation of the cornified envelope
LGALS1 galectin 1
  • Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
  • Post-translational protein phosphorylation
  • Mercaptoethanol
  • Thiodigalactoside
  • 1,4-Dithiothreitol
  • Artenimol
NF1 neurofibromin 1
  • Regulation of RAS by GAPs
  • RAS signaling downstream of NF1 loss-of-function variants
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
PDE4D phosphodiesterase 4D
  • DARPP-32 events
  • G alpha (s) signalling events
  • Adenosine phosphate
  • Caffeine
  • Caffeine
  • Dyphylline
  • Iloprost
  • Amrinone
  • Roflumilast
  • Piclamilast
  • Rolipram
  • 3,5-Dimethyl-1-(3-Nitrophenyl)-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
  • 2-[3-(2-Hydroxy-1,1-Dihydroxymethyl-Ethylamino)-Propylamino]-2-Hydroxymethyl-Propane-1,3-Diol
  • Zardaverine
  • 1-(4-Aminophenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
  • (S)-Rolipram
  • Cilomilast
  • (R)-Rolipram
  • 3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
  • 1-(4-Methoxyphenyl)-3,5-Dimethyl-1h-Pyrazole-4-Carboxylic Acid Ethyl Ester
  • Crisaborole
  • Ibudilast
  • Tetomilast
  • Exisulind
  • (4R)-4-(3-butoxy-4-methoxybenzyl)imidazolidin-2-one
  • 3,5-DIMETHYL-1-PHENYL-1H-PYRAZOLE-4-CARBOXYLIC ACID ETHYL ESTER
  • 3-isobutyl-1-methyl-7H-xanthine
  • 4-[8-(3-nitrophenyl)-1,7-naphthyridin-6-yl]benzoic acid
  • Trapidil
PDE6D phosphodiesterase 6D
  • ARL13B-mediated ciliary trafficking of INPP5E
  • RAS processing
RABGEF1 RAB guanine nucleotide exchange factor 1
  • TBC/RABGAPs
  • RAB GEFs exchange GTP for GDP on RABs
RASGRF1 Ras protein specific guanine nucleotide releasing factor 1
  • Ras activation upon Ca2+ influx through NMDA receptor
  • RAF/MAP kinase cascade
RASGRP4 RAS guanyl releasing protein 4
  • FCERI mediated NF-kB activation
  • RAF/MAP kinase cascade
RGL1 ral guanine nucleotide dissociation stimulator like 1
  • PPARA activates gene expression
  • RAF/MAP kinase cascade
RGS12 regulator of G protein signaling 12
  • G alpha (i) signalling events
  • G alpha (i) signalling events
RHOD ras homolog family member D
  • Rho GTPase cycle
  • RHO GTPases Activate Formins
RSPO3 R-spondin 3
  • Regulation of FZD by ubiquitination
  • RUNX1 regulates transcription of genes involved in WNT signaling
SHOC2 SHOC2 leucine rich repeat scaffold protein
  • RAF activation
  • Signaling by MRAS-complex mutants
  • Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
ARHGAP29 Rho GTPase activating protein 29
  • Rho GTPase cycle
BMPR1A bone morphogenetic protein receptor type 1A
  • Signaling by BMP
  • Dibotermin alfa
  • Hereditary mixed polyposis syndrome
  • Juvenile polyposis syndrome

Page 5 out of 8 pages