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MSH2 |
mutS homolog 2 |
- Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta)
- Defective Mismatch Repair Associated With MSH3
- Defective Mismatch Repair Associated With MSH2
- Defective Mismatch Repair Associated With MSH6
- TP53 Regulates Transcription of DNA Repair Genes
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- Colorectal cancer
- Mismatch repair deficiency, including: Hereditary non-polyposis colorectal cancer (HNPCC); Lynch syndrome; Muir-Torre syndrome; Turcot syndrome
- Ovarian cancer
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PLA2G4B |
phospholipase A2 group IVB |
- Acyl chain remodelling of PC
- Acyl chain remodelling of PS
- Acyl chain remodelling of PE
- Acyl chain remodelling of PG
- Hydrolysis of LPC
- Synthesis of PA
- XBP1(S) activates chaperone genes
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PRKCZ |
protein kinase C zeta |
- GPVI-mediated activation cascade
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- VEGFR2 mediated cell proliferation
- RHO GTPases Activate NADPH Oxidases
- Estrogen-stimulated signaling through PRKCZ
- Estrogen-stimulated signaling through PRKCZ
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RAPGEF1 |
Rap guanine nucleotide exchange factor 1 |
- Frs2-mediated activation
- Frs2-mediated activation
- Downstream signal transduction
- MET activates RAP1 and RAC1
- Erythropoietin activates RAS
- Erythropoietin activates RAS
- Regulation of signaling by CBL
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RASGRP1 |
RAS guanyl releasing protein 1 |
- Effects of PIP2 hydrolysis
- Activation of RAS in B cells
- Activation of RAS in B cells
- FCERI mediated NF-kB activation
- Integrin signaling
- Rap1 signalling
- RAF/MAP kinase cascade
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TLR9 |
toll like receptor 9 |
- PI3K Cascade
- Trafficking and processing of endosomal TLR
- Toll Like Receptor 9 (TLR9) Cascade
- Potential therapeutics for SARS
- TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling
- TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
- MyD88 dependent cascade initiated on endosome
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- Chloroquine
- Hydroxychloroquine
- ISS-1018
- Golotimod
- CPG 10101
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TP73 |
tumor protein p73 |
- Activation of PUMA and translocation to mitochondria
- TP53 Regulates Transcription of Genes Involved in Cytochrome C Release
- TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain
- TP53 Regulates Transcription of Caspase Activators and Caspases
- TP53 Regulates Transcription of Death Receptors and Ligands
- Regulation of TP53 Activity through Association with Co-factors
- RUNX1 regulates transcription of genes involved in differentiation of HSCs
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- Zinc
- Zinc acetate
- Zinc chloride
- Zinc sulfate, unspecified form
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BCL2 |
BCL2 apoptosis regulator |
- Activation of BAD and translocation to mitochondria
- BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
- Interleukin-4 and Interleukin-13 signaling
- The NLRP1 inflammasome
- Estrogen-dependent gene expression
- Estrogen-dependent nuclear events downstream of ESR-membrane signaling
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- Ibuprofen
- Paclitaxel
- Docetaxel
- Rasagiline
- Paclitaxel docosahexaenoic acid
- Apoptone
- Glycine betaine
- Eribulin
- Dexibuprofen
- Isosorbide
- Venetoclax
- Obatoclax
- Navitoclax
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- Choriocarcinoma
- Gastric cancer
- Chronic lymphocytic leukemia (CLL)
- Small cell lung cancer
- Kaposi's sarcoma
- Nasopharyngeal cancer
- Cervical cancer
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BUB1 |
BUB1 mitotic checkpoint serine/threonine kinase |
- Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
- Separation of Sister Chromatids
- Resolution of Sister Chromatid Cohesion
- RHO GTPases Activate Formins
- Mitotic Prometaphase
- EML4 and NUDC in mitotic spindle formation
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EIF3L |
eukaryotic translation initiation factor 3 subunit L |
- L13a-mediated translational silencing of Ceruloplasmin expression
- Translation initiation complex formation
- Formation of a pool of free 40S subunits
- Formation of the ternary complex, and subsequently, the 43S complex
- Ribosomal scanning and start codon recognition
- GTP hydrolysis and joining of the 60S ribosomal subunit
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INSR |
insulin receptor |
- PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
- IRS activation
- Signal attenuation
- Insulin receptor signalling cascade
- Signaling by Insulin receptor
- Insulin receptor recycling
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- Insulin human
- Insulin lispro
- Insulin glargine
- Insulin pork
- Mecasermin
- Insulin aspart
- Insulin detemir
- Insulin glulisine
- Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
- NN344
- AT1391
- [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID
- Chromic chloride
- Insulin degludec
- Fostamatinib
- Brigatinib
- Mecasermin rinfabate
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- Rabson-Mendenhall syndrome
- Leprechaunism ; Donohue syndrome
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KRAS |
KRAS proto-oncogene, GTPase |
- Signaling by moderate kinase activity BRAF mutants
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- RUNX3 regulates p14-ARF
- RAS processing
- RAS GTPase cycle mutants
- Signaling downstream of RAS mutants
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- [(3,7,11-TRIMETHYL-DODECA-2,6,10-TRIENYLOXYCARBAMOYL)-METHYL]-PHOSPHONIC ACID
- Farnesyl diphosphate
- MRTX849
- AMG-510
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- Craniosynostosis, including: Pfeiffer syndrome; Apert syndrome; Crouzon syndrome; Jackson-Weiss syndrome; Beare-Stevenson syndrome; Muenke craniosynostosis; Saethre-Chotzen syndrome; Craniosynostosis Boston type; Antley-Bixler syndrome; Carpenter syndrome; Craniofrontonasal dysplasia; Noonan syndrome; Baller-Gerold syndrome
- Pancreatic cancer
- Gastric cancer
- Colorectal cancer
- Non-small cell lung cancer
- Noonan syndrome and related disorders, including: Noonan syndrome (NS); Leopard syndrome (LS); Noonan syndrome-like with loose anagen hair (NS/LAH); CBL-mutation associated syndrome (CBL); Neurofibromatosis type 1 (NF1); Neurofibromatosis type 2 (NF2); Neurofibromatosis-Noonan syndrome (NFNS); Legius syndrome; Cardiofaciocutaneous syndrome (CFCS); Costello syndrome (CS)
- Oral cancer
- Acute myeloid leukemia (AML)
- Endometrial Cancer
- Multiple myeloma
- Squamous cell carcinoma
- Kaposi's sarcoma
- Cholangiocarcinoma
- Thyroid cancer
- Cervical cancer
- Hepatocellular carcinoma
- Ovarian cancer
- Gallbladder cancer
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MAP2K6 |
mitogen-activated protein kinase kinase 6 |
- NOD1/2 Signaling Pathway
- Oxidative Stress Induced Senescence
- activated TAK1 mediates p38 MAPK activation
- Myogenesis
- PI5P Regulates TP53 Acetylation
- Interleukin-1 signaling
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RAB5C |
RAB5C, member RAS oncogene family |
- Golgi Associated Vesicle Biogenesis
- Neutrophil degranulation
- TBC/RABGAPs
- Clathrin-mediated endocytosis
- RAB geranylgeranylation
- RAB GEFs exchange GTP for GDP on RABs
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RASA1 |
RAS p21 protein activator 1 |
- Downstream signal transduction
- EPHB-mediated forward signaling
- EPHB-mediated forward signaling
- VEGFR2 mediated cell proliferation
- Regulation of RAS by GAPs
- PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
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- RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
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SNRPE |
small nuclear ribonucleoprotein polypeptide E |
- SLBP independent Processing of Histone Pre-mRNAs
- snRNP Assembly
- mRNA Splicing - Major Pathway
- mRNA Splicing - Minor Pathway
- RNA Polymerase II Transcription Termination
- SLBP Dependent Processing of Replication-Dependent Histone Pre-mRNAs
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TIAM1 |
TIAM Rac1 associated GEF 1 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- EPHB-mediated forward signaling
- EPH-ephrin mediated repulsion of cells
- G alpha (12/13) signalling events
- Activated NTRK2 signals through CDK5
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TLR6 |
toll like receptor 6 |
- ER-Phagosome pathway
- MyD88:MAL(TIRAP) cascade initiated on plasma membrane
- Toll Like Receptor TLR6:TLR2 Cascade
- MyD88 deficiency (TLR2/4)
- IRAK4 deficiency (TLR2/4)
- Regulation of TLR by endogenous ligand
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ARHGEF18 |
Rho/Rac guanine nucleotide exchange factor 18 |
- NRAGE signals death through JNK
- Rho GTPase cycle
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
- G alpha (12/13) signalling events
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BRAP |
BRCA1 associated protein |
- RAF activation
- Negative regulation of MAPK pathway
- Signaling by moderate kinase activity BRAF mutants
- Paradoxical activation of RAF signaling by kinase inactive BRAF
- Signaling downstream of RAS mutants
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