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STUB1 |
STIP1 homology and U-box containing protein 1 |
- Downregulation of TGF-beta receptor signaling
- RIPK1-mediated regulated necrosis
- Regulation of necroptotic cell death
- Downregulation of ERBB2 signaling
- Regulation of RUNX2 expression and activity
- Regulation of PTEN stability and activity
- Antigen processing: Ubiquitination & Proteasome degradation
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TAX1BP3 |
Tax1 binding protein 3 |
- RHO GTPases Activate Rhotekin and Rhophilins
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TBL1X |
transducin beta like 1 X-linked |
- RORA activates gene expression
- BMAL1:CLOCK,NPAS2 activates circadian gene expression
- PPARA activates gene expression
- PPARA activates gene expression
- NOTCH1 Intracellular Domain Regulates Transcription
- Transcriptional activation of mitochondrial biogenesis
- Activation of gene expression by SREBF (SREBP)
- Constitutive Signaling by NOTCH1 PEST Domain Mutants
- Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
- HDACs deacetylate histones
- Notch-HLH transcription pathway
- Transcriptional regulation of white adipocyte differentiation
- Regulation of lipid metabolism by PPARalpha
- Circadian Clock
- Loss of MECP2 binding ability to the NCoR/SMRT complex
- Regulation of MECP2 expression and activity
- NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
- HCMV Early Events
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TCF7L1 |
transcription factor 7 like 1 |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- Deactivation of the beta-catenin transactivating complex
- Ca2+ pathway
- Binding of TCF/LEF:CTNNB1 to target gene promoters
- Repression of WNT target genes
- Repression of WNT target genes
- RUNX3 regulates WNT signaling
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TLE1 |
TLE family member 1, transcriptional corepressor |
- Formation of the beta-catenin:TCF transactivating complex
- NOTCH1 Intracellular Domain Regulates Transcription
- Deactivation of the beta-catenin transactivating complex
- Repression of WNT target genes
- Repression of WNT target genes
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TRIM33 |
tripartite motif containing 33 |
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
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TRIM55 |
tripartite motif containing 55 |
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TRIM63 |
tripartite motif containing 63 |
- FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
- Antigen processing: Ubiquitination & Proteasome degradation
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TRIP10 |
thyroid hormone receptor interactor 10 |
- Rho GTPase cycle
- Clathrin-mediated endocytosis
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TRRAP |
transformation/transcription domain associated protein |
- Formation of the beta-catenin:TCF transactivating complex
- Formation of the beta-catenin:TCF transactivating complex
- HATs acetylate histones
- Ub-specific processing proteases
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UBE2B |
ubiquitin conjugating enzyme E2 B |
- Recognition of DNA damage by PCNA-containing replication complex
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2D1 |
ubiquitin conjugating enzyme E2 D1 |
- Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha
- Inactivation of APC/C via direct inhibition of the APC/C complex
- TICAM1, RIP1-mediated IKK complex recruitment
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Signaling by BMP
- Downstream TCR signaling
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- FCERI mediated NF-kB activation
- CLEC7A (Dectin-1) signaling
- Ovarian tumor domain proteases
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- E3 ubiquitin ligases ubiquitinate target proteins
- Neddylation
- Peroxisomal protein import
- Negative regulators of DDX58/IFIH1 signaling
- IKK complex recruitment mediated by RIP1
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2R2 |
ubiquitin conjugating enzyme E2 R2 |
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Antigen processing: Ubiquitination & Proteasome degradation
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UBE2S |
ubiquitin conjugating enzyme E2 S |
- Inactivation of APC/C via direct inhibition of the APC/C complex
- APC/C:Cdc20 mediated degradation of Cyclin B
- Autodegradation of Cdh1 by Cdh1:APC/C
- APC/C:Cdc20 mediated degradation of Securin
- APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
- Cdc20:Phospho-APC/C mediated degradation of Cyclin A
- Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase
- Regulation of APC/C activators between G1/S and early anaphase
- APC/C:Cdc20 mediated degradation of mitotic proteins
- Phosphorylation of the APC/C
- APC-Cdc20 mediated degradation of Nek2A
- Separation of Sister Chromatids
- Senescence-Associated Secretory Phenotype (SASP)
- CDK-mediated phosphorylation and removal of Cdc6
- Transcriptional Regulation by VENTX
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Aberrant regulation of mitotic exit in cancer due to RB1 defects
- Antigen processing: Ubiquitination & Proteasome degradation
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UHRF2 |
ubiquitin like with PHD and ring finger domains 2 |
- SUMOylation of transcription cofactors
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USP2 |
ubiquitin specific peptidase 2 |
- TNFR1-induced proapoptotic signaling
- Regulation of TNFR1 signaling
- TNFR1-induced NFkappaB signaling pathway
- Ub-specific processing proteases
- Regulation of TP53 Degradation
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USP9X |
ubiquitin specific peptidase 9 X-linked |
- Downregulation of SMAD2/3:SMAD4 transcriptional activity
- Ub-specific processing proteases
- Synthesis of active ubiquitin: roles of E1 and E2 enzymes
- Peroxisomal protein import
- Peroxisomal protein import
- Amyloid fiber formation
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ZFYVE9 |
zinc finger FYVE-type containing 9 |
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