Search Results for: CHEK2

Novel Interactant Symbol Name
Associated Pathways
Binding Drugs
Associated Diseases
SIAH2 siah E3 ubiquitin protein ligase 2
  • Netrin-1 signaling
  • Ub-specific processing proteases
  • Amyloid fiber formation
  • Antigen processing: Ubiquitination & Proteasome degradation
CCL5 C-C motif chemokine ligand 5
  • Chemokine receptors bind chemokines
  • G alpha (i) signalling events
  • Interleukin-10 signaling
  • Heparin Disaccharide I-S
  • Heparin Disaccharide Iii-S
CYP17A1 cytochrome P450 family 17 subfamily A member 1
  • Androgen biosynthesis
  • Glucocorticoid biosynthesis
  • Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)
  • NADH
  • Progesterone
  • Spironolactone
  • Ketoconazole
  • Abiraterone
  • Cannabidiol
  • Medical Cannabis
  • Nabiximols
  • 46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS)
  • Congenital adrenal hyperplasia (CAH)
ENO1 enolase 1
  • Glycolysis
  • Gluconeogenesis
  • Manipulation of host energy metabolism
  • Zinc
  • Copper
  • Artenimol
  • Zinc acetate
  • Zinc chloride
  • Zinc sulfate, unspecified form
MRC1 mannose receptor C-type 1
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Cross-presentation of soluble exogenous antigens (endosomes)
  • Modulation by Mtb of host immune system
  • Technetium Tc-99m tilmanocept
NR4A1 nuclear receptor subfamily 4 group A member 1
  • AKT phosphorylates targets in the nucleus
  • Nuclear Receptor transcription pathway
  • Constitutive Signaling by AKT1 E17K in Cancer
REV3L REV3 like, DNA directed polymerase zeta catalytic subunit
  • Translesion synthesis by REV1
  • Translesion synthesis by POLK
  • Translesion synthesis by POLI
DBF4 DBF4 zinc finger
  • Activation of ATR in response to replication stress
  • Activation of the pre-replicative complex
ELAVL1 ELAV like RNA binding protein 1
  • HuR (ELAVL1) binds and stabilizes mRNA
  • mRNA Splicing - Major Pathway
FOXM1 forkhead box M1
  • Polo-like kinase mediated events
  • Cyclin A/B1/B2 associated events during G2/M transition
MUS81 MUS81 structure-specific endonuclease subunit
  • Resolution of D-loop Structures through Holliday Junction Intermediates
  • Fanconi Anemia Pathway
PLK3 polo like kinase 3
  • TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain
  • Regulation of TP53 Activity through Phosphorylation
  • Fostamatinib
RCHY1 ring finger and CHY zinc finger domain containing 1
  • Translesion Synthesis by POLH
  • Antigen processing: Ubiquitination & Proteasome degradation
ST14 ST14 transmembrane serine protease matriptase
  • Formation of the cornified envelope
  • Formation of the cornified envelope
  • Urokinase
  • Benzamidine
  • Camostat
  • Ichthyosis with hypotrichosis
STRAP serine/threonine kinase receptor associated protein
  • Downregulation of TGF-beta receptor signaling
  • Downregulation of TGF-beta receptor signaling
AATF apoptosis antagonizing transcription factor
  • NRAGE signals death through JNK
ARHGAP1 Rho GTPase activating protein 1
  • Rho GTPase cycle
ASF1A anti-silencing function 1A histone chaperone
  • Formation of Senescence-Associated Heterochromatin Foci (SAHF)
CDH13 cadherin 13
  • Adherens junctions interactions
CDK11B cyclin dependent kinase 11B
  • Recruitment of mitotic centrosome proteins and complexes

Page 3 out of 5 pages