CHEK2 - Wiki-MPM

Interactant Symbol	Name	Associated Pathways Hide	Binding Drugs Hide	Associated Diseases Hide
SIAH2	siah E3 ubiquitin protein ligase 2	Netrin-1 signaling Ub-specific processing proteases Amyloid fiber formation Antigen processing: Ubiquitination & Proteasome degradation
CCL5	C-C motif chemokine ligand 5	Chemokine receptors bind chemokines G alpha (i) signalling events Interleukin-10 signaling	Heparin Disaccharide I-S Heparin Disaccharide Iii-S
CYP17A1	cytochrome P450 family 17 subfamily A member 1	Androgen biosynthesis Glucocorticoid biosynthesis Defective CYP17A1 causes Adrenal hyperplasia 5 (AH5)	NADH Progesterone Spironolactone Ketoconazole Abiraterone Cannabidiol Medical Cannabis Nabiximols	46,XY disorders of sex development (Disorders in androgen synthesis or action), including: Congenital adrenal hyperplasias; Leydig cell hypoplasia; Androgen insensitivity syndrome (AIS) Congenital adrenal hyperplasia (CAH)
ENO1	enolase 1	Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
MRC1	mannose receptor C-type 1	Cross-presentation of soluble exogenous antigens (endosomes) Cross-presentation of soluble exogenous antigens (endosomes) Modulation by Mtb of host immune system	Technetium Tc-99m tilmanocept
NR4A1	nuclear receptor subfamily 4 group A member 1	AKT phosphorylates targets in the nucleus Nuclear Receptor transcription pathway Constitutive Signaling by AKT1 E17K in Cancer
REV3L	REV3 like, DNA directed polymerase zeta catalytic subunit	Translesion synthesis by REV1 Translesion synthesis by POLK Translesion synthesis by POLI
DBF4	DBF4 zinc finger	Activation of ATR in response to replication stress Activation of the pre-replicative complex
ELAVL1	ELAV like RNA binding protein 1	HuR (ELAVL1) binds and stabilizes mRNA mRNA Splicing - Major Pathway
FOXM1	forkhead box M1	Polo-like kinase mediated events Cyclin A/B1/B2 associated events during G2/M transition
MUS81	MUS81 structure-specific endonuclease subunit	Resolution of D-loop Structures through Holliday Junction Intermediates Fanconi Anemia Pathway
PLK3	polo like kinase 3	TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation	Fostamatinib
RCHY1	ring finger and CHY zinc finger domain containing 1	Translesion Synthesis by POLH Antigen processing: Ubiquitination & Proteasome degradation
ST14	ST14 transmembrane serine protease matriptase	Formation of the cornified envelope Formation of the cornified envelope	Urokinase Benzamidine Camostat	Ichthyosis with hypotrichosis
STRAP	serine/threonine kinase receptor associated protein	Downregulation of TGF-beta receptor signaling Downregulation of TGF-beta receptor signaling
AATF	apoptosis antagonizing transcription factor	NRAGE signals death through JNK
ARHGAP1	Rho GTPase activating protein 1	Rho GTPase cycle
ASF1A	anti-silencing function 1A histone chaperone	Formation of Senescence-Associated Heterochromatin Foci (SAHF)
CDH13	cadherin 13	Adherens junctions interactions
CDK11B	cyclin dependent kinase 11B	Recruitment of mitotic centrosome proteins and complexes

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