MED24 and PPARA

Data Source:
HPRD (in vitro)

		MED24	PPARA
Description		mediator complex subunit 24	peroxisome proliferator activated receptor alpha
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Mediator Complex	Chromatin Nucleus Nucleoplasm
	Molecular Function	Transcription Coregulator Activity Transcription Coactivator Activity Protein Binding Nuclear Receptor Coactivator Activity Vitamin D Receptor Binding Thyroid Hormone Receptor Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Sequence-specific DNA Binding Protein-containing Complex Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding
	Biological Process	Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Fatty Acid Metabolic Process Heart Development Epidermis Development Cellular Response To Starvation Hormone-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Localization Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Response To Lipid Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Response To Ethanol Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Fatty Acid Transport Negative Regulation Of Signaling Receptor Activity Positive Regulation Of ATP Biosynthetic Process
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation	RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors
Drugs			alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil
Diseases
GWAS		Asthma ( 31619474) Bipolar disorder ( 31043756) Eosinophil counts ( 32888494) Estimated glomerular filtration rate ( 31152163) Mitochondrial DNA copy number ( 30704525) Neutrophil count ( 25096241 29403010) Neutrophil percentage of white cells ( 32888494) Pancreatic ductal adenocarcinoma ( 30541042) Pursuit maintenance gain ( 29064472) Refractive error ( 32231278) White blood cell count ( 22037903 32888494 20139978 21738480 28158719)	Cholesterol, total ( 24097068) CTACK levels ( 27989323) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Impulsivity (motor) ( 30718321) LDL cholesterol ( 24097068) Refractive error ( 32231278) Resting-state electroencephalogram vigilance ( 29703947) Triglyceride levels ( 32203549) Type 2 diabetes ( 31049640) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)
Interacting Genes		14 interacting genes: APP AR CTDP1 ESR1 ESR2 GSK3B HNF4A MED9 PPARA PPARG RPS6KA6 RXRA SREBF1 TNFSF11	70 interacting genes: AIP AKAP13 ANKRD11 AQP1 BCL2 CCDC179 CDC34 CDK3 CEP350 CHD9 CHIC2 COL8A1 CTNNA3 DAP3 DUT EP300 EXOSC4 FABP1 FAM90A1 FAM9B FBLN1 FOXA3 GADD45A GADD45B GADD45G GPANK1 HELZ2 HOXC8 HSP90AA1 KCTD7 KRTAP10-1 LAMTOR5 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H2 NR1H3 NRBF2 NRIP1 PAQR3 PICK1 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SDCBP SIRT1 STAC3 TNP1 TRIM55 TRIM63 UBE2I VWA5A VWC2L ZNF587 ZSCAN23
Entrez ID		9862	5465
HPRD ID		06107	01369
Ensembl ID		ENSG00000008838	ENSG00000186951
Uniprot IDs		F5GY88 O75448	F1D8S4 Q07869
PDB IDs			1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96
Enriched GO Terms of Interacting Partners?
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