PPARA and BCL2

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		PPARA	BCL2
Description		peroxisome proliferator activated receptor alpha	BCL2 apoptosis regulator
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm	Nucleus Nucleoplasm Cytoplasm Mitochondrion Mitochondrial Outer Membrane Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Membrane Nuclear Membrane Protein-containing Complex Myelin Sheath Pore Complex
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Repressing Transcription Factor Binding Transcription Coactivator Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Steroid Hormone Receptor Activity Nuclear Receptor Activity Protein Binding Transcription Factor Binding Drug Binding Zinc Ion Binding Lipid Binding Phosphatase Binding Protein Domain Specific Binding Ubiquitin Conjugating Enzyme Binding Sequence-specific DNA Binding Protein-containing Complex Binding NFAT Protein Binding MDM2/MDM4 Family Protein Binding	Protease Binding Protein Binding Channel Activity Channel Inhibitor Activity Ubiquitin Protein Ligase Binding Identical Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding Protein Heterodimerization Activity BH3 Domain Binding Protein Phosphatase 2A Binding Repressing Transcription Factor Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Response To Hypoxia Transcription Initiation From RNA Polymerase II Promoter Fatty Acid Metabolic Process Heart Development Epidermis Development Cellular Response To Starvation Hormone-mediated Signaling Pathway Regulation Of Cellular Ketone Metabolic Process Negative Regulation Of Macrophage Derived Foam Cell Differentiation Lipid Localization Negative Regulation Of Cholesterol Storage Negative Regulation Of Sequestering Of Triglyceride Regulation Of Lipid Metabolic Process Regulation Of Fatty Acid Metabolic Process Cell Differentiation Negative Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Intracellular Receptor Signaling Pathway Positive Regulation Of Fatty Acid Beta-oxidation Negative Regulation Of Protein Binding Negative Regulation Of Appetite Response To Insulin Circadian Regulation Of Gene Expression Response To Lipid Behavioral Response To Nicotine Wound Healing Lipoprotein Metabolic Process Regulation Of Circadian Rhythm Steroid Hormone Mediated Signaling Pathway Positive Regulation Of Viral Genome Replication Response To Ethanol Positive Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Glycolytic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Fatty Acid Oxidation Positive Regulation Of Lipid Biosynthetic Process Negative Regulation Of Inflammatory Response Negative Regulation Of Protein Kinase B Signaling Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Enamel Mineralization Negative Regulation Of Cytokine Production Involved In Inflammatory Response Negative Regulation Of Neuron Death Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of Hepatocyte Apoptotic Process Regulation Of Fatty Acid Transport Negative Regulation Of Signaling Receptor Activity Positive Regulation Of ATP Biosynthetic Process	Protein Polyubiquitination Ossification Ovarian Follicle Development Metanephros Development Branching Involved In Ureteric Bud Morphogenesis Behavioral Fear Response B Cell Homeostasis Release Of Cytochrome C From Mitochondria Regulation Of Cell-matrix Adhesion Lymphoid Progenitor Cell Differentiation B Cell Lineage Commitment Response To Ischemia Renal System Process Protein Dephosphorylation Melanin Metabolic Process Regulation Of Nitrogen Utilization Apoptotic Process Humoral Immune Response Cellular Response To DNA Damage Stimulus Actin Filament Organization Axonogenesis Female Pregnancy Cell Aging Positive Regulation Of Cell Population Proliferation Male Gonad Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress Response To Radiation Response To Toxic Substance Post-embryonic Development Response To Iron Ion Response To UV-B Response To Gamma Radiation Regulation Of Gene Expression Negative Regulation Of Autophagy Negative Regulation Of Calcium Ion Transport Into Cytosol Regulation Of Glycoprotein Biosynthetic Process Mesenchymal Cell Development Positive Regulation Of Neuron Maturation Positive Regulation Of Smooth Muscle Cell Migration Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cytokine-mediated Signaling Pathway Cochlear Nucleus Development Gland Morphogenesis Regulation Of Transmembrane Transporter Activity Negative Regulation Of Ossification Positive Regulation Of Cell Growth Negative Regulation Of Cell Growth Melanocyte Differentiation Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Hair Follicle Morphogenesis Axon Regeneration Regulation Of Protein Stability Endoplasmic Reticulum Calcium Ion Homeostasis Glomerulus Development Negative Regulation Of Cellular PH Reduction Negative Regulation Of Myeloid Cell Apoptotic Process T Cell Differentiation In Thymus Positive Regulation Of Peptidyl-serine Phosphorylation Negative Regulation Of Osteoblast Proliferation Response To Cytokine Response To Nicotine Organ Growth Positive Regulation Of Multicellular Organism Growth B Cell Proliferation Cellular Response To Glucose Starvation Response To Drug Response To Hydrogen Peroxide T Cell Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of Catalytic Activity CD8-positive, Alpha-beta T Cell Lineage Commitment Negative Regulation Of Neuron Apoptotic Process Ear Development Regulation Of Viral Genome Replication Positive Regulation Of Melanocyte Differentiation Negative Regulation Of Retinal Cell Programmed Cell Death Regulation Of Mitochondrial Membrane Permeability Focal Adhesion Assembly Spleen Development Thymus Development Digestive Tract Morphogenesis Oocyte Development Positive Regulation Of Skeletal Muscle Fiber Development Pigment Granule Organization Homeostasis Of Number Of Cells Within A Tissue B Cell Receptor Signaling Pathway Response To Glucocorticoid Neuron Apoptotic Process Defense Response To Virus Regulation Of Mitochondrial Membrane Potential Negative Regulation Of Mitochondrial Depolarization Regulation Of Calcium Ion Transport Transmembrane Transport Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Hypoxia Reactive Oxygen Species Metabolic Process Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Cell-cell Adhesion Positive Regulation Of Protein Insertion Into Mitochondrial Membrane Involved In Apoptotic Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle Negative Regulation Of Reactive Oxygen Species Metabolic Process Negative Regulation Of Anoikis Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		RORA activates gene expression BMAL1:CLOCK,NPAS2 activates circadian gene expression PPARA activates gene expression PPARA activates gene expression Transcriptional activation of mitochondrial biogenesis Activation of gene expression by SREBF (SREBP) Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock SUMOylation of intracellular receptors	Activation of BAD and translocation to mitochondria BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members Interleukin-4 and Interleukin-13 signaling The NLRP1 inflammasome Estrogen-dependent gene expression Estrogen-dependent nuclear events downstream of ESR-membrane signaling
Drugs		alpha-Linolenic acid Icosapent Troglitazone Valproic acid Indomethacin Rosiglitazone Fenoprofen Clofibrate Fenofibrate Ibuprofen Amiodarone Gemfibrozil Bezafibrate Prasterone N,N-Bis(3-(D-gluconamido)propyl)deoxycholamide Flufenamic acid Resveratrol Phthalic Acid Lauric acid Stearic acid Doconexent Palmitic Acid Oleic Acid Caprylic acid Arachidonic Acid Reglitazar Elafibranor Cardarine Muraglitazar Ertiprotafib Ragaglitazar Tesaglitazar GW-590735 Indeglitazar Myristic acid Aleglitazar Clinofibrate Ciprofibrate Dexibuprofen Soybean oil Omega-3 fatty acids Myrrh Isoflavone Leukotriene B4 Fenofibric acid Fish oil	Ibuprofen Paclitaxel Docetaxel Rasagiline Paclitaxel docosahexaenoic acid Apoptone Glycine betaine Eribulin Dexibuprofen Isosorbide Venetoclax Obatoclax Navitoclax
Diseases			Choriocarcinoma Gastric cancer Chronic lymphocytic leukemia (CLL) Small cell lung cancer Kaposi's sarcoma Nasopharyngeal cancer Cervical cancer
GWAS		Cholesterol, total ( 24097068) CTACK levels ( 27989323) Eosinophil counts ( 32888494) Eosinophil percentage of white cells ( 32888494) Impulsivity (motor) ( 30718321) LDL cholesterol ( 24097068) Refractive error ( 32231278) Resting-state electroencephalogram vigilance ( 29703947) Triglyceride levels ( 32203549) Type 2 diabetes ( 31049640) Very long-chain saturated fatty acid levels (fatty acid 20:0) ( 25378659)	Adult body size ( 32376654) Albumin-globulin ratio ( 29403010) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Body mass index ( 28892062 25673413) Cardiac Troponin-T levels ( 23247143) Chronic lymphocytic leukemia ( 28165464 26956414 23770605) Eosinophil counts ( 32888494 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 32888494 27863252) Excessive hairiness ( 29895819) Follicular lymphoma ( 25279986) Heel bone mineral density ( 30598549) High light scatter reticulocyte count ( 32888494 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte counts ( 32888494 27863252) Lymphocyte percentage of white cells ( 32888494) Male-pattern baldness ( 28196072) Mean corpuscular hemoglobin ( 32888494 27863252) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Modified Stumvoll Insulin Sensitivity Index (BMI interaction) ( 27416945) Modified Stumvoll Insulin Sensitivity Index (model adjusted for BMI) ( 27416945) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494 27863252) Mosaic loss of chromosome Y (Y chromosome dosage) ( 28346444 31624269) Multiple sclerosis ( 31604244) Neutrophil count ( 32888494) Neutrophil percentage of granulocytes ( 27863252) Neutrophil percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Prostate cancer ( 29892016) Pyoderma gangrenosum in inflammatory bowel disease ( 24487271) Red blood cell count ( 32888494 27863252) Response to adalimumab in hidradenitis suppurativa (abscess and inflammatory nodule count increase) ( 31465739) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494) Serum omega-6 polyunsaturated fatty acid concentration in metabolic syndrome ( 31991592) Serum total protein level ( 29403010) Sum eosinophil basophil counts ( 27863252) Systolic blood pressure ( 30224653 30578418) Triglyceride levels ( 32203549) Triglycerides ( 30275531) Type 2 diabetes ( 28869590) Waist-to-hip ratio adjusted for BMI (adjusted for smoking behaviour) ( 28443625) Waist-to-hip ratio adjusted for body mass index ( 25673412) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		70 interacting genes: AIP AKAP13 ANKRD11 AQP1 BCL2 CCDC179 CDC34 CDK3 CEP350 CHD9 CHIC2 COL8A1 CTNNA3 DAP3 DUT EP300 EXOSC4 FABP1 FAM90A1 FAM9B FBLN1 FOXA3 GADD45A GADD45B GADD45G GPANK1 HELZ2 HOXC8 HSP90AA1 KCTD7 KRTAP10-1 LAMTOR5 MAPK1 MAPK3 MECR MED1 MED24 NCOA1 NCOA2 NCOA3 NCOR1 NCOR2 NR1H2 NR1H3 NRBF2 NRIP1 PAQR3 PICK1 PIK3R3 POU1F1 PPARGC1A PPARGC1B PRKCA PRKCD PRMT1 PRMT8 RELA RXRA RXRG SDCBP SIRT1 STAC3 TNP1 TRIM55 TRIM63 UBE2I VWA5A VWC2L ZNF587 ZSCAN23	87 interacting genes: ATP2A2 BAD BAG1 BAG3 BAG4 BAK1 BAX BBC3 BCAP31 BCL2L1 BCL2L10 BCL2L11 BCL2L12 BCL2L14 BCLAF1 BECN1 BFAR BID BIK BLK BMF BNIP1 BNIP2 BNIP3 BNIP3L BNIPL CAPN2 CASP3 CASP8 CDK1 CDK2 CPT1A CYCS FKBP8 HNRNPD HRAS HRK HSPA1A ITM2B ITPR1 KRAS MAPK1 MAPK11 MAPK14 MAPK3 MAPK8 MEX3D MOAP1 MYC NLRP1 NMT2 NR4A1 NRAS PARP1 PIN1 PKMYT1 PMAIP1 PML PPARA PPID PPP1CA PPP2CA PPP2R5A PPP3CA PPP3CC PRKACA PRKCA PSEN1 PXN RAD9A RAF1 RNF183 RRAS RTN4 SEPTIN4 SF1 SMN1 SOD1 SPHK2 SPNS1 SQSTM1 TMBIM6 TOMM20 TP53 TP53AIP1 TP53BP2 XIAP
Entrez ID		5465	596
HPRD ID		01369	01045
Ensembl ID		ENSG00000186951	ENSG00000171791
Uniprot IDs		F1D8S4 Q07869	A0A024R2B3 A0A024R2C4 P10415
PDB IDs		1I7G 1K7L 1KKQ 2NPA 2P54 2REW 2ZNN 3ET1 3FEI 3G8I 3KDT 3KDU 3SP6 3VI8 4BCR 4CI4 5AZT 5HYK 6KXX 6KXY 6L96	1G5M 1GJH 1YSW 2O21 2O22 2O2F 2W3L 2XA0 4AQ3 4IEH 4LVT 4LXD 4MAN 5AGW 5AGX 5FCG 5JSN 5VAU 5VAX 5VAY 6GL8 6IWB 6O0K 6O0L 6O0M 6O0O 6O0P
Enriched GO Terms of Interacting Partners?
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