GIT2 and GUSB

Data Source:
BioGRID (two hybrid)

		GIT2	GUSB
Description		GIT ArfGAP 2	glucuronidase beta
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Focal Adhesion	Extracellular Region Extracellular Space Membrane Azurophil Granule Lumen Lysosomal Lumen Intracellular Membrane-bounded Organelle Extracellular Exosome Ficolin-1-rich Granule Lumen
	Molecular Function	GTPase Activator Activity Protein Binding Metal Ion Binding	Beta-glucuronidase Activity Signaling Receptor Binding Protein Domain Specific Binding Carbohydrate Binding
	Biological Process	Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of GTPase Activity	Carbohydrate Metabolic Process Glycosaminoglycan Catabolic Process Glucuronoside Catabolic Process Hyaluronan Catabolic Process Neutrophil Degranulation
Pathways			HS-GAG degradation Hyaluronan uptake and degradation MPS VII - Sly syndrome Neutrophil degranulation
Drugs
Diseases			Mucopolysaccharidosis type VII (MPS7); Sly syndrome
GWAS		Bipolar disorder ( 31043756) Disturbances of the gamma-frequency band of electroencephalography measures in schizophrenia ( 28922980) Metabolic syndrome ( 20694148) Metabolite levels ( 23823483) Metabolite levels (MHPG) ( 23319000)
Interacting Genes		48 interacting genes: ACTG1 ACTN1 ARHGEF6 ARHGEF7 ATF5 C4BPA CALCOCO2 CDC42 CORO1A E2F2 EDC4 GCH1 GET4 GIT1 GRK2 GUSB HGD HNRNPUL1 IKBKG KCTD5 KRT18 LAMTOR5 LMNB1 MVP NFKBIB NME2 PAK1 PAK3 PCLO POLR1B PROX1 PXN QPRT RCVRN RUFY1 RUSC2 SAFB2 SH3GLB2 SMAD3 SPOP TGFB1I1 TNFAIP3 TNIP1 TRAF1 TSN UBQLN1 USHBP1 YWHAG	3 interacting genes: CES1 GIT2 PRKACA
Entrez ID		9815	2990
HPRD ID		09779	02018
Ensembl ID		ENSG00000139436	ENSG00000169919
Uniprot IDs		F8VXI9 F8W822 Q14161 Q68DM7 Q6FI58	P08236
PDB IDs			1BHG 3HN3
Enriched GO Terms of Interacting Partners?
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