SART3 and MIRLET7C

Data Source:
BioGRID (unspecified method)

		SART3	MIRLET7C
Description		spliceosome associated factor 3, U4/U6 recycling protein	microRNA let-7c
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm U6atac SnRNP Cytoplasm Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex ASAP Complex U4/U6 SnRNP U4atac/U6atac SnRNP	Extracellular Space Nucleus Cytoplasm Extracellular Exosome Extracellular Vesicle
	Molecular Function	RNA Binding Protein Binding U6 SnRNA Binding U4 SnRNA Binding U6atac SnRNA Binding Histone Binding Ubiquitin-specific Protease Binding	MRNA Binding Involved In Posttranscriptional Gene Silencing
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly Spliceosomal SnRNP Assembly MRNA Splicing, Via Spliceosome Nucleosome Assembly Regulation Of Gene Expression Positive Regulation Of Histone Deubiquitination	Negative Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-8 Production Gene Silencing By MiRNA Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6-mediated Signaling Pathway Negative Regulation Of Receptor Signaling Pathway Via STAT
Pathways
Drugs
Diseases		Disseminated superficial actinic porokeratosis (DSAP)
GWAS		Acne (severe) ( 24927181)
Interacting Genes		29 interacting genes: AR C6 COIL H2AC20 H2BC21 KPNA2 LSM7 MEGF10 MIR1-1 MIR128-2 MIR143 MIR18A MIR18B MIR19B2 MIR200B MIR200C MIR221 MIR34A MIR34B MIR7-1 MIR7-3 MIRLET7C MIRLET7D MIRLET7E MIRLET7F1 PRPF3 RNPS1 ZNF620 ZNF71	96 interacting genes: ADARB1 AIMP1 AIMP2 APOBEC3B ATXN2L C1QBP CHERP CPSF1 CPSF6 DARS1 DDX1 DDX21 DDX3X DHX36 EDC4 EIF2AK2 EPRS1 ERAL1 ESRP1 FAM98A FUS G3BP2 GRSF1 HNRNPA0 HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPF HNRNPH1 HNRNPH2 HNRNPH3 HNRNPK HNRNPL HNRNPM HNRNPR IARS1 IGF2BP1 IGF2BP2 IGF2BP3 KARS1 KNOP1 LARP7 LARS1 LIN28A LIN28B LRPPRC MARS1 MATR3 MSI1 MSI2 NOL6 NONO NUDT16L1 NUDT21 NUFIP2 PDCD11 PLOD1 PTBP1 PTBP3 PUF60 PURA QARS1 RARS1 RBFOX2 RBM12B RBM14 RBM4 RBM4B RBMS2 RTCA RTCB SART3 SF3A1 SF3B1 SF3B2 SF3B3 SF3B4 SFPQ SPOUT1 STRBP SUGP2 SYNCRIP TAF15 TENT2 TRA2A TRA2B TUT4 TUT7 U2SURP UPF1 UTP20 YBX1 YBX2 YBX3 ZFR ZNF346
Entrez ID		9733	406885
HPRD ID		11532
Ensembl ID		ENSG00000075856	ENSG00000199030
Uniprot IDs		A0A499FI31 Q15020
PDB IDs		2DO4 5CTQ 5CTR 5CTT 5JJW 5JJX 5JPZ
Enriched GO Terms of Interacting Partners?
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