DOCK4 and ELMO2

Data Source:
BioGRID (two hybrid, affinity chromatography technology)

		DOCK4	ELMO2
Description		dedicator of cytokinesis 4	engulfment and cell motility 2
Image		No pdb structure
GO Annotations	Cellular Component	Nucleolus Golgi Apparatus Cytosol Plasma Membrane Membrane Stereocilium Stereocilium Bundle	Cytosol Membrane
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding PDZ Domain Binding Receptor Tyrosine Kinase Binding Small GTPase Binding	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding
	Biological Process	Small GTPase Mediated Signal Transduction Positive Regulation Of GTPase Activity Cell Chemotaxis Negative Regulation Of Vascular Associated Smooth Muscle Contraction Positive Regulation Of Vascular Associated Smooth Muscle Cell Migration	Apoptotic Process Actin Filament Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Cell Chemotaxis Cell-cell Adhesion
Pathways		Factors involved in megakaryocyte development and platelet production	Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Body mass index (change over time) ( 25378290) C-reactive protein and white blood cell count ( 22788528) Migraine ( 27322543) Refractive astigmatism ( 30306274) Refractive error ( 32231278) Response to fenofibrate ( 22890011) Total intracranial volume ( 31530798)
Interacting Genes		4 interacting genes: ELMO2 FASLG GRB2 RNF115	3 interacting genes: DOCK1 DOCK4 RHOG
Entrez ID		9732	63916
HPRD ID		07407	12103
Ensembl ID		ENSG00000128512	ENSG00000062598
Uniprot IDs		Q8N1I0	Q96JJ3
PDB IDs			6IDX 6IE1
Enriched GO Terms of Interacting Partners?
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