ELMO2 and DOCK1

Data Source:
HPRD (two hybrid, in vitro)

		ELMO2	DOCK1
Description		engulfment and cell motility 2	dedicator of cytokinesis 1
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GO Annotations	Cellular Component	Cytosol Membrane	Nucleoplasm Cytoplasm Cytosol Membrane Nuclear Speck Guanyl-nucleotide Exchange Factor Complex
	Molecular Function	Protein Binding SH3 Domain Binding Receptor Tyrosine Kinase Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Apoptotic Process Actin Filament Organization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Vascular Endothelial Growth Factor Receptor Signaling Pathway Cell Motility Cell Chemotaxis Cell-cell Adhesion	Phagocytosis, Engulfment Apoptotic Process Signal Transduction Integrin-mediated Signaling Pathway Small GTPase Mediated Signal Transduction Blood Coagulation Positive Regulation Of Epithelial Cell Migration Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of GTPase Activity Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Substrate Adhesion-dependent Cell Spreading
Pathways		Regulation of actin dynamics for phagocytic cup formation VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis	Regulation of actin dynamics for phagocytic cup formation DCC mediated attractive signaling DCC mediated attractive signaling VEGFA-VEGFR2 Pathway PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases FCGR3A-mediated phagocytosis Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS			Airway wall thickness ( 25517131) Apolipoprotein Levels ( 23031429) Body mass index ( 25673413) Body mass index (change over time) in gastrointestinal cancer ( 28044437) Body mass index (change over time) in gastrointestinal cancer or chronic obstructive pulmonary disease ( 28044437) BRCA1/2-negative high-risk breast cancer ( 30323354) Chronotype ( 30696823) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Homeostasis model assessment of insulin resistance in less-fat diet ( 30327367) Response to cytidine analogues (gemcitabine) ( 24483146) Response to TNF inhibitor in rheumatoid arthritis (change in disease activity score) ( 30166627) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Social communication problems ( 24564958) Weight ( 28552196)
Interacting Genes		3 interacting genes: DOCK1 DOCK4 RHOG	11 interacting genes: BCAR1 CRK CYTH2 ELMO1 ELMO2 NCK2 PRKACA RAC1 RHOG TAMALIN WASF2
Entrez ID		63916	1793
HPRD ID		12103	03240
Ensembl ID		ENSG00000062598	ENSG00000150760
Uniprot IDs		Q96JJ3	A0A2X0U2H5 B2RUU3 Q14185
PDB IDs		6IDX 6IE1	3L4C
Enriched GO Terms of Interacting Partners?
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