CD74 and FXYD6

Data Source:
BioGRID (two hybrid)

		CD74	FXYD6
Description		CD74 molecule	FXYD domain containing ion transport regulator 6
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Lysosomal Membrane Multivesicular Body Vacuole Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Integral Component Of Membrane Transport Vesicle Membrane Endocytic Vesicle Membrane Clathrin-coated Endocytic Vesicle Membrane Trans-Golgi Network Membrane Protein-containing Complex Macrophage Migration Inhibitory Factor Receptor Complex NOS2-CD74 Complex MHC Class II Protein Complex Lysosomal Lumen Extracellular Exosome Integral Component Of Lumenal Side Of Endoplasmic Reticulum Membrane	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Amyloid-beta Binding Cytokine Receptor Activity Protein Binding Cytokine Binding MHC Class II Protein Complex Binding Macrophage Migration Inhibitory Factor Binding MHC Class II Protein Binding CD4 Receptor Binding MHC Class II Protein Binding, Via Antigen Binding Groove Identical Protein Binding Protein Folding Chaperone Nitric-oxide Synthase Binding	Molecular_function Protein Binding Sodium Channel Regulator Activity Ion Channel Regulator Activity
	Biological Process	Activation Of MAPK Activity Prostaglandin Biosynthetic Process Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cytokine-mediated Signaling Pathway T Cell Activation Involved In Immune Response Positive Regulation Of Dendritic Cell Antigen Processing And Presentation Negative Regulation Of Peptide Secretion Positive Regulation Of Type 2 Immune Response Negative Regulation Of Mature B Cell Apoptotic Process Intracellular Protein Transport Cell Population Proliferation Positive Regulation Of Gene Expression Immunoglobulin Mediated Immune Response Antigen Processing And Presentation Antigen Processing And Presentation Of Endogenous Antigen Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Negative Regulation Of Cell Migration Positive Regulation Of B Cell Proliferation Positive Regulation Of Prostaglandin Biosynthetic Process Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Interleukin-8 Production Positive Regulation Of Kinase Activity Response To Interferon-gamma Macrophage Migration Inhibitory Factor Signaling Pathway Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of MAPK Cascade Negative Regulation Of DNA Damage Response, Signal Transduction By P53 Class Mediator T Cell Selection Positive Thymic T Cell Selection Negative Thymic T Cell Selection Negative Regulation Of T Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Monocyte Differentiation Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Viral Entry Into Host Cell Positive Regulation Of Fibroblast Proliferation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Leukocyte Migration Chaperone Cofactor-dependent Protein Refolding Positive Regulation Of Macrophage Cytokine Production Protein-containing Complex Assembly Protein Trimerization Positive Regulation Of ERK1 And ERK2 Cascade Positive Regulation Of Neutrophil Chemotaxis Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator Positive Regulation Of Chemokine (C-X-C Motif) Ligand 2 Production Positive Regulation Of Macrophage Migration Inhibitory Factor Signaling Pathway	Biological_process Ion Transmembrane Transport Regulation Of Cardiac Conduction Regulation Of Sodium Ion Transmembrane Transporter Activity
Pathways		Cell surface interactions at the vascular wall MHC class II antigen presentation	Ion homeostasis Ion transport by P-type ATPases Potential therapeutics for SARS
Drugs
Diseases
GWAS		Crohn's disease ( 28067908) Inflammatory bowel disease ( 28067908) Post bronchodilator FEV1/FVC ratio ( 26634245)	Hippocampal volume in Alzheimer's disease dementia ( 29274321) Myopia ( 27182965)
Interacting Genes		44 interacting genes: APP BET1 C14orf180 CCR1 CD1D CD44 CLDN19 CLEC7A CMTM7 CTSF CTSL EDDM3B ERG28 FDFT1 FXYD6 HADHA HLA-DMA HLA-DMB HLA-DPA1 HLA-DPB1 HLA-DQA1 HLA-DQB1 HLA-DRA LAMTOR5 LPAR3 MAP3K1 MIF PGA4 PLP1 PLPP4 POMGNT1 PTCH1 RTP2 SEC22A SERP1 SLC35B1 SMIM1 TEX11 TMEM120B TMEM243 TMEM254 TMEM60 TMEM97 UPK2	65 interacting genes: APCDD1L APH1A AQP6 ARL13B BCAR1 C4BPA CCDC90B CD74 CERS4 CLDN7 CLEC10A CREB3 CREB3L1 DERL2 EBP ELOVL2 ELOVL4 ERGIC3 FCER1G FFAR2 FPR2 GDF9 GJA8 GPR42 HAUS2 JAGN1 KCNJ6 LHFPL2 LHFPL5 LMNA MFF MGST3 MMGT1 OCIAD1 PEX12 PGRMC2 PPP1CC RBM48 RHBDL1 RHCG RNASEK SLC10A1 SLC10A6 SLC16A7 SLC30A2 SLC35C2 SLC35E1 SLC35E3 SLC39A2 SLC47A1 SVOP TLCD4 TLE1 TM4SF18 TMEM154 TMEM237 TMEM239 TMEM31 TMEM35A TMEM72 TMEM86B TMPPE TP53 TRIM27 UNC119
Entrez ID		972	53826
HPRD ID		00825	09456
Ensembl ID		ENSG00000019582	ENSG00000137726
Uniprot IDs		P04233	A0A024R3J8 Q9H0Q3
PDB IDs		1A6A 1ICF 1IIE 1L3H 1MUJ 3PDO 3PGC 3PGD 3QXA 3QXD 4AEN 4AH2 4X5W 5KSU 5KSV
Enriched GO Terms of Interacting Partners?
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