DEPDC5 and DPPA3

Data Source:
BioGRID (two hybrid)

		DEPDC5	DPPA3
Description		DEP domain containing 5, GATOR1 subcomplex subunit	developmental pluripotency associated 3
Image			No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Cytosol Cul3-RING Ubiquitin Ligase Complex Perinuclear Region Of Cytoplasm GATOR1 Complex	Female Pronucleus Male Pronucleus Nucleus Cytoplasm
	Molecular Function	GTPase Activator Activity Protein-containing Complex Binding	Protein Binding Methylated Histone Binding
	Biological Process	Regulation Of Autophagy Negative Regulation Of TOR Signaling Cellular Response To Amino Acid Starvation Intracellular Signal Transduction Positive Regulation Of GTPase Activity Negative Regulation Of TORC1 Signaling	Chromatin Organization Protection Of DNA Demethylation Of Female Pronucleus Negative Regulation Of DNA Demethylation Regulation Of Genetic Imprinting
Pathways		Amino acids regulate mTORC1
Drugs
Diseases
GWAS		Age-related hearing impairment ( 24939585) Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Chronic hepatitis C infection ( 21725309) Fish- and plant-related diet ( 32066663) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Intelligence ( 22449649) Isthmus-cingulate cortex volume ( 31530798) Oily fish consumption ( 32066663) Pork consumption ( 32066663) Type 2 diabetes ( 30130595)	Borderline personality disorder ( 28632202) White matter hyperintensities in ischemic stroke ( 26674333)
Interacting Genes		10 interacting genes: CCT3 DPPA3 MAD2L1 MAD2L2 MEOX2 MTMR9 RRAGB RRAGC SYT17 USP2	14 interacting genes: DEPDC5 DYNLL1 DYNLL2 HAUS7 IPO5 KRT27 KRT76 NUP62 PLEKHG4 SERTAD3 SYCE1L TFIP11 TRIB3 ZNF618
Entrez ID		9681	359787
HPRD ID		16795	16331
Ensembl ID		ENSG00000100150	ENSG00000187569
Uniprot IDs		O75140	Q6W0C5
PDB IDs		6CES 6CET
Enriched GO Terms of Interacting Partners?
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