SOCS5 and TMBIM1

Data Source:
BioGRID (two hybrid)

		SOCS5	TMBIM1
Description		suppressor of cytokine signaling 5	transmembrane BAX inhibitor motif containing 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol Phosphatidylinositol 3-kinase Complex	Lysosomal Membrane Golgi Apparatus Plasma Membrane Endosome Membrane Integral Component Of Membrane Specific Granule Membrane Intracellular Membrane-bounded Organelle Extracellular Exosome
	Molecular Function	Epidermal Growth Factor Receptor Binding Protein Binding Receptor Tyrosine Kinase Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Death Receptor Binding Protein Binding
	Biological Process	Epidermal Growth Factor Receptor Signaling Pathway Negative Regulation Of Epidermal Growth Factor-activated Receptor Activity Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Signal Transduction Protein Ubiquitination Cytokine-mediated Signaling Pathway Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Interleukin-6 Production Intracellular Signal Transduction Regulation Of Growth Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Positive Regulation Of T-helper 1 Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Phosphatidylinositol Phosphorylation Negative Regulation Of Inflammatory Response Cellular Response To Low-density Lipoprotein Particle Stimulus Negative Regulation Of Monocyte Chemotactic Protein-1 Production Vascular Endothelial Cell Response To Fluid Shear Stress	Negative Regulation Of Catalytic Activity Neutrophil Degranulation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Fas Signaling Pathway Negative Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Blood Vessel Remodeling
Pathways		Interleukin-4 and Interleukin-13 signaling Neddylation	Neutrophil degranulation
Drugs
Diseases
GWAS		Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Cerebrospinal P-tau181p levels ( 28247064) Chronotype ( 30696823) Current cigarettes per day in chronic obstructive pulmonary disease ( 21685187) Height ( 28552196 20881960) Offspring birth weight ( 31043758) Pulse pressure (alcohol consumption interaction) ( 24376456)	Colorectal cancer ( 28960316) Colorectal cancer or advanced adenoma ( 30510241) Gallstone disease ( 30504769) High light scatter reticulocyte count ( 27863252) High light scatter reticulocyte percentage of red cells ( 32888494) Inflammatory bowel disease ( 28067908 23128233) Red cell distribution width ( 27863252) Reticulocyte count ( 32888494 27863252) Reticulocyte fraction of red cells ( 32888494 27863252)
Interacting Genes		11 interacting genes: APP CASP3 EGFR ERBB2 ERBB3 ERBB4 IL4R KIT MET TMBIM1 UBC	13 interacting genes: B3GALNT2 BIK CD33 F2RL1 GGT6 PROK2 RCHY1 RIC3 SLC10A1 SOCS5 TMEM242 TRIM55 TRIM63
Entrez ID		9655	64114
HPRD ID		06159	17884
Ensembl ID		ENSG00000171150	ENSG00000135926
Uniprot IDs		O75159	A0A024R472 B3KSM0 B4DUD2 Q969X1
PDB IDs
Enriched GO Terms of Interacting Partners?
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