AATK and DUSP9

Data Source:
BioGRID (two hybrid)

		AATK	DUSP9
Description		apoptosis associated tyrosine kinase	dual specificity phosphatase 9
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Integral Component Of Membrane Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Cytosol
	Molecular Function	Protein Kinase Activity Protein Tyrosine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Phosphoprotein Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/threonine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Mitogen-activated Protein Kinase Binding Protein Serine Phosphatase Activity Protein Threonine Phosphatase Activity
	Biological Process	Protein Phosphorylation Brain Development Biological_process Peptidyl-tyrosine Autophosphorylation	MAPK Cascade Activation Of MAPK Activity Inactivation Of MAPK Activity Protein Dephosphorylation JNK Cascade Peptidyl-tyrosine Dephosphorylation Peptidyl-threonine Dephosphorylation Positive Regulation Of Apoptotic Process Regulation Of Heart Growth Negative Regulation Of ERK1 And ERK2 Cascade
Pathways			RAF-independent MAPK1/3 activation Negative regulation of MAPK pathway Signaling by MAPK mutants
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Beef consumption ( 32066663) Lymphocyte percentage of white cells ( 32888494) Neuroticism ( 29255261) Neutrophil count ( 32888494) Neutrophil percentage of white cells ( 32888494) Obesity-related traits ( 23251661) Serum uric acid levels in response to allopurinol in gout ( 25676789)	Body mass index ( 28892062) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate ( 29403010) Hemoglobin A1c levels ( 29403010) Type 2 diabetes ( 23945395 22961080 20581827 30718926)
Interacting Genes		43 interacting genes: BDKRB2 CDC14A CDC25B CDK5 DUSP1 DUSP14 DUSP29 DUSP5 DUSP6 DUSP9 ERBB2 EYA2 EYA4 ILKAP MTMR10 MTMR6 MTMR8 MTMR9 PPM1A PPM1B PPM1F PPM1K PPM1M PPP1CA PPP1CB PPP1CC PPP3CA PPP3CB PTEN PTPDC1 PTPN11 PTPN12 PTPN18 PTPN20 PTPN6 PTPN7 PTPRR SBF1 STK39 STYX TAB1 TEPSIN TPTE2	7 interacting genes: AATK CDK4 GSK3B MAPK1 MAPK10 MAPK14 MAPK3
Entrez ID		9625	1852
HPRD ID		05591	02136
Ensembl ID		ENSG00000181409	ENSG00000130829
Uniprot IDs		H7C175 Q6ZMQ8	B2RAL9 Q6P9C2 Q99956
PDB IDs			2HXP 3LJ8
Enriched GO Terms of Interacting Partners?
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