ABCG1 and ABCG4

Data Source:
HPRD (in vitro, in vivo)

		ABCG1	ABCG4
Description		ATP binding cassette subfamily G member 1	ATP binding cassette subfamily G member 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Mitochondrion Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Recycling Endosome	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Protein Binding ATP Binding Phospholipid Binding Cholesterol Binding ATPase Activity Toxin Transmembrane Transporter Activity ABC-type Sterol Transporter Activity Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Phosphatidylcholine Floppase Activity Cholesterol Transfer Activity Floppase Activity	Protein Binding ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cholesterol Metabolic Process Response To Organic Substance Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Lipid Lipid Translocation Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Glycoprotein Transport Cholesterol Homeostasis Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Protein Secretion Transmembrane Transport Phospholipid Homeostasis Intermembrane Lipid Transfer Toxin Transport Positive Regulation Of Amyloid-beta Formation	Cholesterol Efflux Transmembrane Transport Cellular Response To Leukemia Inhibitory Factor
Pathways		ABC transporters in lipid homeostasis HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux	ABC transporters in lipid homeostasis
Drugs		ATP
Diseases
GWAS		Amyotrophic lateral sclerosis (sporadic) ( 24529757) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Eating disorder in bipolar disorder ( 26433762) Gout ( 22179738) HDL cholesterol levels ( 32203549) Idiopathic osteonecrosis of the femoral head ( 28000841) Neuritic plaque ( 25188341)	Lymphocyte counts ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252)
Interacting Genes		2 interacting genes: ABCG4 AQP6	6 interacting genes: ABCG1 GPR152 PLEKHF2 SGTB TMEM50A ZDHHC17
Entrez ID		9619	64137
HPRD ID		04355	12130
Ensembl ID		ENSG00000160179	ENSG00000172350
Uniprot IDs		P45844	Q9H172
PDB IDs
Enriched GO Terms of Interacting Partners?
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