ABCG4 and ABCG1

Data Source:
HPRD (in vitro, in vivo)

		ABCG4	ABCG1
Description		ATP binding cassette subfamily G member 4	ATP binding cassette subfamily G member 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane	Golgi Membrane Mitochondrion Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Recycling Endosome
	Molecular Function	Protein Binding ATP Binding ATPase Activity ATPase-coupled Transmembrane Transporter Activity Identical Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity	Protein Binding ATP Binding Phospholipid Binding Cholesterol Binding ATPase Activity Toxin Transmembrane Transporter Activity ABC-type Sterol Transporter Activity Protein Homodimerization Activity ADP Binding Protein Heterodimerization Activity Phosphatidylcholine Floppase Activity Cholesterol Transfer Activity Floppase Activity
	Biological Process	Cholesterol Efflux Transmembrane Transport Cellular Response To Leukemia Inhibitory Factor	Cholesterol Metabolic Process Response To Organic Substance Negative Regulation Of Macrophage Derived Foam Cell Differentiation Regulation Of Cholesterol Esterification Negative Regulation Of Cholesterol Storage Intracellular Cholesterol Transport Cholesterol Efflux Phospholipid Efflux Response To Lipid Lipid Translocation Low-density Lipoprotein Particle Remodeling High-density Lipoprotein Particle Remodeling Glycoprotein Transport Cholesterol Homeostasis Amyloid Precursor Protein Catabolic Process Reverse Cholesterol Transport Positive Regulation Of Cholesterol Biosynthetic Process Positive Regulation Of Protein Secretion Transmembrane Transport Phospholipid Homeostasis Intermembrane Lipid Transfer Toxin Transport Positive Regulation Of Amyloid-beta Formation
Pathways		ABC transporters in lipid homeostasis	ABC transporters in lipid homeostasis HDL remodeling NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
Drugs			ATP
Diseases
GWAS		Lymphocyte counts ( 27863252) Monocyte percentage of white cells ( 32888494) Neutrophil percentage of white cells ( 32888494 27863252)	Amyotrophic lateral sclerosis (sporadic) ( 24529757) Dementia and core Alzheimer's disease neuropathologic changes ( 25188341) Eating disorder in bipolar disorder ( 26433762) Gout ( 22179738) HDL cholesterol levels ( 32203549) Idiopathic osteonecrosis of the femoral head ( 28000841) Neuritic plaque ( 25188341)
Interacting Genes		6 interacting genes: ABCG1 GPR152 PLEKHF2 SGTB TMEM50A ZDHHC17	2 interacting genes: ABCG4 AQP6
Entrez ID		64137	9619
HPRD ID		12130	04355
Ensembl ID		ENSG00000172350	ENSG00000160179
Uniprot IDs		Q9H172	P45844
PDB IDs
Enriched GO Terms of Interacting Partners?
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