NCOR1 and CXADR

Data Source:
BioGRID (two hybrid)

		NCOR1	CXADR
Description		nuclear receptor corepressor 1	CXADR Ig-like cell adhesion molecule
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GO Annotations	Cellular Component	Histone Deacetylase Complex Chromatin Nucleus Nucleoplasm Cytosol Membrane Sin3 Complex Transcription Repressor Complex Mitotic Spindle	Acrosomal Vesicle Extracellular Region Nucleoplasm Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Basolateral Plasma Membrane Apicolateral Plasma Membrane Cell Junction Filopodium Growth Cone Protein-containing Complex Neuron Projection Cell Body Membrane Raft
	Molecular Function	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Activating Transcription Factor Binding Transcription Corepressor Activity Protein Binding Nuclear Hormone Receptor Binding Histone Deacetylase Binding Thyroid Hormone Receptor Binding	Virus Receptor Activity Integrin Binding Protein Binding Beta-catenin Binding PDZ Domain Binding Cell Adhesion Molecule Binding Connexin Binding Cell Adhesive Protein Binding Involved In AV Node Cell-bundle Of His Cell Communication
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Circadian Rhythm Regulation Of Lipid Metabolic Process Locomotor Rhythm Negative Regulation Of Glycolytic Process Negative Regulation Of Transcription, DNA-templated Negative Regulation Of Fatty Acid Metabolic Process Negative Regulation Of JNK Cascade Spindle Assembly Negative Regulation Of Androgen Receptor Signaling Pathway Negative Regulation Of Production Of MiRNAs Involved In Gene Silencing By MiRNA	Mitochondrion Organization Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Heart Development Germ Cell Migration Epithelial Structure Maintenance Neutrophil Chemotaxis Actin Cytoskeleton Reorganization Cell-cell Junction Organization Gamma-delta T Cell Activation Viral Entry Into Host Cell Cardiac Muscle Fiber Development Regulation Of Immune Response Leukocyte Migration Transepithelial Transport AV Node Cell To Bundle Of His Cell Communication AV Node Cell-bundle Of His Cell Adhesion Involved In Cell Communication Regulation Of AV Node Cell Action Potential
Pathways		Nuclear signaling by ERBB4 Nuclear signaling by ERBB4 NR1D1 (REV-ERBA) represses gene expression PPARA activates gene expression PPARA activates gene expression NOTCH1 Intracellular Domain Regulates Transcription Transcriptional activation of mitochondrial biogenesis Downregulation of SMAD2/3:SMAD4 transcriptional activity Downregulation of SMAD2/3:SMAD4 transcriptional activity Constitutive Signaling by NOTCH1 PEST Domain Mutants Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants HDACs deacetylate histones Notch-HLH transcription pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation Nuclear Receptor transcription pathway Regulation of lipid metabolism by PPARalpha Circadian Clock Circadian Clock Activation of anterior HOX genes in hindbrain development during early embryogenesis Loss of MECP2 binding ability to the NCoR/SMRT complex Regulation of MECP2 expression and activity NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux HCMV Early Events NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Adult body size ( 32376654) C-reactive protein levels ( 30388399) FEV1 ( 30804560) Free thyroxine concentration ( 30367059) Lung function (FEV1) ( 26635082) Lung function (FVC) ( 30804560) Lymphocyte counts ( 32888494) Monocyte count ( 32888494)	Neutrophil count ( 32888494)
Interacting Genes		89 interacting genes: ACTN2 AR ATXN1 ATXN1L ATXN3 BCL6 C1D CBFA2T2 CHD1 CHUK CLK1 CNOT2 COPS2 CSNK2A1 CXADR DACH1 DDX20 DHX30 DZIP3 ENO1 ESR1 ESR2 ETS1 ETS2 GPS2 GTF2B H3C1 H4C1 HDAC3 HDAC5 HDAC9 HESX1 HEY2 HTT KLF5 MECP2 MYB MYBL2 MYOD1 NCOA1 NCOA3 NCOR2 NELFE NR1D1 NR1D2 NR1H2 NR1H3 NR2E3 NR3C1 NR6A1 PDCD2 PHB PIAS1 PML POU1F1 PPARA PPARD PPARG PTMA RARA RARG RBPJ RUNX1 RUNX1T1 RXRA SAFB SAP30 SKI SKIL SNW1 SP1 SPEN SQSTM1 SUMO2 TAB2 TAF6 TAF9 TBL1X TBL1XR1 THRA THRB TRIM14 TULP3 TXNRD2 VDR ZBTB16 ZBTB33 ZBTB7A ZMYND11	10 interacting genes: ANKRD46 EWSR1 FAM3C JAML LNX1 LNX2 MAL NCOA1 NCOR1 VKORC1
Entrez ID		9611	1525
HPRD ID		02911	11804
Ensembl ID		ENSG00000141027	ENSG00000154639
Uniprot IDs		A0A024RD47 O75376 Q6PGR4	P78310
PDB IDs		2EQR 3H52 3KMZ 3N00 4MDD 4WVD 6ONI	1EAJ 1F5W 1JEW 1KAC 1P69 1P6A 1RSF 2J12 2J1K 2NPL 2W9L 2WBW 3J6L 3J6M 3J6N 3J6O
Enriched GO Terms of Interacting Partners?
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