GABBR2 and HTR1A

Data Source:
HPRD (in vivo)

		GABBR2	HTR1A
Description		gamma-aminobutyric acid type B receptor subunit 2	5-hydroxytryptamine receptor 1A
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane G Protein-coupled Receptor Heterodimeric Complex Neuron Projection Postsynaptic Membrane GABA Receptor Complex	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse
	Molecular Function	Transmembrane Signaling Receptor Activity G Protein-coupled GABA Receptor Activity Protein Binding Protein Heterodimerization Activity	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction
	Biological Process	G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Adenylate Cyclase Activity Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Neuron-glial Cell Signaling	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior
Pathways		Activation of G protein gated Potassium channels G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) GABA B receptor activation Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits	Serotonin receptors
Drugs		Baclofen gamma-Aminobutyric acid SGS-742 Arbaclofen Arbaclofen Placarbil	Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856
Diseases
GWAS		Gynecologic disease (multivariate analysis) ( 31488892) High chromosomal aberration frequency (chromatid type) ( 31586183) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) Pulse pressure x alcohol consumption interaction (2df test) ( 29912962) Response to simvastatin treatment (PCSK9 protein level change) ( 25089948) Response to TNF inhibitor in rheumatoid arthritis (change in tender 28-joint count) ( 30166627) Schizophrenia ( 30285260) Systolic blood pressure change trajectories ( 27980656)	Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)
Interacting Genes		11 interacting genes: ATF4 ATF5 DRD2 GABBR1 GLP1R HTR1A KCTD12 KCTD16 NSF SH3GL3 TAMALIN	8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3
Entrez ID		9568	3350
HPRD ID		09552	00190
Ensembl ID		ENSG00000136928	ENSG00000178394
Uniprot IDs		H9NIL8 O75899	A8K5W4 P08908 Q5ZGX3
PDB IDs		4F11 4F12 4MQE 4MQF 4MR7 4MR8 4MR9 4MRM 4MS1 4MS3 4MS4 4PAS 6M8R 6OCP 6UO8 6UO9 6UOA 6VJM 6W2X 6WIV 7C7Q 7C7S
Enriched GO Terms of Interacting Partners?
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