HTR1A and GPR26

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo, in vitro)

		HTR1A	GPR26
Description		5-hydroxytryptamine receptor 1A	G protein-coupled receptor 26
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Dendrite Synapse	Plasma Membrane Integral Component Of Membrane
	Molecular Function	G Protein-coupled Serotonin Receptor Activity Protein Binding Neurotransmitter Receptor Activity Serotonin Binding Receptor-receptor Interaction	G Protein-coupled Receptor Activity
	Biological Process	Behavioral Fear Response G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting Serotonin Receptor Signaling Pathway Serotonin Receptor Signaling Pathway Gamma-aminobutyric Acid Signaling Pathway Chemical Synaptic Transmission Positive Regulation Of Cell Population Proliferation Regulation Of Serotonin Secretion Regulation Of Vasoconstriction Exploration Behavior Regulation Of Dopamine Metabolic Process Serotonin Metabolic Process Regulation Of Hormone Secretion Regulation Of Behavior	G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Serotonin receptors
Drugs		Eletriptan Ziprasidone Methysergide Cabergoline Zolmitriptan Amitriptyline Olanzapine Clozapine Loxapine Pramipexole Methylphenidate Imipramine Chlorpromazine Buspirone Haloperidol Nortriptyline Amoxapine Propranolol Fenfluramine Lisuride Trazodone Sumatriptan Ergotamine Apomorphine Paroxetine Trimipramine Risperidone Alprenolol Ondansetron Naratriptan Pindolol Dopamine Ergoloid mesylate Doxepin Nefazodone Desipramine Escitalopram Pergolide Bromocriptine Ketamine Quetiapine Aripiprazole Chlorprothixene Paliperidone Penbutolol Yohimbine Acepromazine Alverine Molindone Pipotiazine Thioproperazine Lysergic acid diethylamide Dapoxetine Bifeprunox Flibanserin Iloperidone Lofexidine Lesopitron Rotigotine MN-305 LI-301 Naluzotan Cariprazine Mianserin Pizotifen Asenapine Xaliproden Dotarizine Sarizotan Repinotan Robalzotan Vilazodone Bopindolol Cinitapride Lurasidone Perospirone Cannabidiol Vortioxetine Brexpiprazole Dosulepin Pirlindole Tianeptine Setiptiline Dihydroergocornine Tetrahydrocannabivarin Pardoprunox Gilteritinib Tiapride Dihydroergocristine Medical Cannabis 5-methoxy-N,N-dimethyltryptamine Nabiximols Aripiprazole lauroxil SEP-363856
Diseases
GWAS		Adult body size ( 32376654) Alcohol and nicotine co-dependence ( 23216389) Body mass index ( 20935630) Bronchopulmonary dysplasia ( 23897914) Fasting insulin (dietary factor interaction) ( 24204828) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) White matter lesion progression ( 26451028) White matter lesion progression (adjusted for white matter lesion burden at baseline) ( 26451028)	Adult body size ( 32376654) Body mass index ( 28892062) Cardiac Troponin-T levels ( 23247143) Chronotype ( 30696823) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Hepcidin/ferritin ratio ( 27846281) Motion sickness ( 25628336) Night sleep phenotypes ( 27126917) Right lateral prefrontal cortical growth ( 29682794)
Interacting Genes		8 interacting genes: FGFR1 GABBR2 GNAI3 GPR26 HTR1B HTR1D S1PR1 S1PR3	1 interacting genes: HTR1A
Entrez ID		3350	2849
HPRD ID		00190	07275
Ensembl ID		ENSG00000178394	ENSG00000154478
Uniprot IDs		A8K5W4 P08908 Q5ZGX3	Q8NDV2
PDB IDs
Enriched GO Terms of Interacting Partners?
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