SEC22B and B3GAT3

Data Source:
BioGRID (two hybrid)

		SEC22B	B3GAT3
Description		SEC22 homolog B, vesicle trafficking protein	beta-1,3-glucuronyltransferase 3
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GO Annotations	Cellular Component	Golgi Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Synaptic Vesicle ER To Golgi Transport Vesicle Membrane Integral Component Of Membrane Transport Vesicle COPI-coated Vesicle Phagocytic Vesicle Membrane SNARE Complex Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Melanosome	Golgi Membrane Golgi Apparatus Cis-Golgi Network Membrane Integral Component Of Membrane Extracellular Exosome
	Molecular Function	SNAP Receptor Activity Protein Binding Syntaxin Binding	Protein Binding Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase Activity Glucuronosyltransferase Activity Metal Ion Binding Protein Phosphatase Activator Activity
	Biological Process	Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Protein Transport Positive Regulation Of Protein Catabolic Process COPII Vesicle Coating Vesicle Fusion With Golgi Apparatus Negative Regulation Of Autophagosome Assembly Vesicle Fusion With Endoplasmic Reticulum-Golgi Intermediate Compartment (ERGIC) Membrane	Carbohydrate Metabolic Process Glycosaminoglycan Biosynthetic Process Protein Glycosylation Heparan Sulfate Proteoglycan Biosynthetic Process Glycosaminoglycan Metabolic Process Positive Regulation Of Catalytic Activity Regulation Of Phosphoprotein Phosphatase Activity Chondroitin Sulfate Proteoglycan Biosynthetic Process Dermatan Sulfate Proteoglycan Biosynthetic Process Positive Regulation Of Intracellular Protein Transport
Pathways		ER-Phagosome pathway COPII-mediated vesicle transport Cargo concentration in the ER COPI-dependent Golgi-to-ER retrograde traffic	A tetrasaccharide linker sequence is required for GAG synthesis Defective B3GAT3 causes JDSSDHD
Drugs			UDP-alpha-D-glucuronic acid Uridine-5'-Diphosphate
Diseases
GWAS		Iris color (L* coordinate) ( 30895295)	Blood protein levels ( 29875488) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		56 interacting genes: ABHD16A AIG1 AQP6 B3GAT3 CD79A CERS6 CLDN7 CLRN1 CPLX4 CREB3 CREB3L1 DPM3 EBP ELOVL4 ERGIC3 FAM174A FAM209A FCER1G FNDC9 GJA8 GJB5 GJB6 GORAB GPR152 GPX8 HIBADH HSD17B11 HSD17B13 IFNGR2 JAGN1 KIR2DL3 LHFPL1 LHFPL5 LMNA MFF MFSD5 MGST2 MGST3 MMGT1 MRPS18B NDUFAF2 REEP4 RELL2 RHBDD1 SERINC2 SLC35C2 STX1A STX2 STX4 STX5 TLCD4 TM4SF19 TMEM139 TMEM167B TMEM229B TMEM86B	5 interacting genes: CCR2 CCR4 GPR35 HNRNPD SEC22B
Entrez ID		9554	26229
HPRD ID		04939	07564
Ensembl ID		ENSG00000265808	ENSG00000149541
Uniprot IDs		O75396	G3V150 O94766 Q5U676
PDB IDs		2NUP 2NUT 3EGD 3EGX	1FGG 1KWS 3CU0
Enriched GO Terms of Interacting Partners?
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