KIF23 and RACGAP1

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		KIF23	RACGAP1
Description		kinesin family member 23	Rac GTPase activating protein 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Centrosome Spindle Cytosol Kinesin Complex Microtubule Focal Adhesion Midbody Mitotic Spindle Flemming Body Centralspindlin Complex	Acrosomal Vesicle Nucleus Nucleoplasm Spindle Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding
	Biological Process	Mitotic Spindle Elongation Mitotic Cytokinesis Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Mitotic Spindle Midzone Assembly	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Spermatogenesis Neuroblast Proliferation Sulfate Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore
Pathways		MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Mitotic Telophase/Cytokinesis Kinesins	Rho GTPase cycle MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Rheumatoid arthritis (ACPA-positive) ( 24532676)
Interacting Genes		13 interacting genes: ACTA1 ARF3 CLK1 LATS2 PLK1 PPP1CB RACGAP1 RBM34 SUMO2 USP8 YWHAB YWHAG YWHAQ	32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG
Entrez ID		9493	29127
HPRD ID		05455	05402
Ensembl ID		ENSG00000137807	ENSG00000161800
Uniprot IDs		Q02241	A0A024R136 B2RE34 Q9H0H5
PDB IDs		3VHX	2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?
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