RACGAP1 and SLC26A8

Data Source:
HPRD (two hybrid, in vitro)

		RACGAP1	SLC26A8
Description		Rac GTPase activating protein 1	solute carrier family 26 member 8
Image			No pdb structure
GO Annotations	Cellular Component	Acrosomal Vesicle Nucleus Nucleoplasm Spindle Cytosol Microtubule Midbody Extrinsic Component Of Cytoplasmic Side Of Plasma Membrane Cleavage Furrow Spindle Midzone Extracellular Exosome Mitotic Spindle Flemming Body Centralspindlin Complex	Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	GTPase Activator Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Protein Kinase Binding Alpha-tubulin Binding Gamma-tubulin Binding Metal Ion Binding Beta-tubulin Binding	Chloride Channel Activity Protein Binding Secondary Active Sulfate Transmembrane Transporter Activity Bicarbonate Transmembrane Transporter Activity Chloride Transmembrane Transporter Activity Sulfate Transmembrane Transporter Activity Anion:anion Antiporter Activity Oxalate Transmembrane Transporter Activity
	Biological Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Spermatogenesis Neuroblast Proliferation Sulfate Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Positive Regulation Of Cytokinesis Intracellular Signal Transduction Positive Regulation Of GTPase Activity Regulation Of Embryonic Development Regulation Of Small GTPase Mediated Signal Transduction Mitotic Spindle Midzone Assembly Regulation Of Attachment Of Spindle Microtubules To Kinetochore	Anion Transport Chloride Transport Multicellular Organism Development Sulfate Transport Bicarbonate Transport Oxalate Transport Flagellated Sperm Motility Sperm Capacitation Meiotic Cell Cycle Sulfate Transmembrane Transport Chloride Transmembrane Transport
Pathways		Rho GTPase cycle MHC class II antigen presentation COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS			Antidepressant treatment resistance (> 2 drugs prescribed) ( 30700811)
Interacting Genes		32 interacting genes: AURKB BYSL CDK1 CDK3 CHN2 ECT2 HIF1A KIF23 MAP3K10 MAP3K4 MORF4L1 MPRIP NRAS PLK1 PPP2CA PPP2R5E PRC1 PRSS23 PTPA RAC1 RND2 SH3RF1 SLC16A10 SLC26A8 TANK TRAF3IP3 TUBA4A TUBG1 TXNDC11 VAV1 YWHAB YWHAG	1 interacting genes: RACGAP1
Entrez ID		29127	116369
HPRD ID		05402	12241
Ensembl ID		ENSG00000161800	ENSG00000112053
Uniprot IDs		A0A024R136 B2RE34 Q9H0H5	A0A024RCV0 Q96RN1
PDB IDs		2OVJ 3W6R 3WPQ 3WPS 4B6D 5C2J 5C2K
Enriched GO Terms of Interacting Partners?
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