CD36 and ITGA6

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		CD36	ITGA6
Description		CD36 molecule	integrin subunit alpha 6
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Space Cytoplasm Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola External Side Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Endocytic Vesicle Membrane Platelet Alpha Granule Membrane Brush Border Membrane Specific Granule Membrane Receptor Complex Membrane Raft Phagocytic Vesicle Cell Periphery	Plasma Membrane Adherens Junction Focal Adhesion Cell Surface Filopodium Integrin Alpha6-beta4 Complex
	Molecular Function	Amyloid-beta Binding Low-density Lipoprotein Particle Receptor Activity Scavenger Receptor Activity Long-chain Fatty Acid Transporter Activity Protein Binding High-density Lipoprotein Particle Binding Lipid Binding Short-chain Fatty Acid Transmembrane Transporter Activity Low-density Lipoprotein Particle Binding Toll-like Receptor Binding Protein-containing Complex Binding Transforming Growth Factor Beta Binding Thrombospondin Receptor Activity Lipoteichoic Acid Immune Receptor Activity Lipoprotein Particle Binding Oxidised Low-density Lipoprotein Particle Receptor Activity Oleate Transmembrane Transporter Activity	Protein Binding Insulin-like Growth Factor I Binding Neuregulin Binding Laminin Binding Protein-containing Complex Binding Cadherin Binding Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Cell-matrix Adhesion Toll-like Receptor Signaling Pathway Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Production Of Molecular Mediator Involved In Inflammatory Response Platelet Degranulation MyD88-dependent Toll-like Receptor Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Receptor-mediated Endocytosis Phagocytosis, Recognition Phagocytosis, Engulfment Cell Adhesion Positive Regulation Of Cytosolic Calcium Ion Concentration Nitric Oxide Mediated Signal Transduction Blood Coagulation Positive Regulation Of Gene Expression Positive Regulation Of Macrophage Derived Foam Cell Differentiation Positive Regulation Of Cholesterol Storage Positive Regulation Of Cell Death Long-chain Fatty Acid Transport Long-chain Fatty Acid Import Across Plasma Membrane Short-chain Fatty Acid Transport Regulation Of Lipid Metabolic Process Cytokine-mediated Signaling Pathway Lipid Storage CGMP-mediated Signaling Positive Regulation Of Blood Coagulation Intestinal Cholesterol Absorption Cholesterol Transport Receptor Internalization Regulation Of Lipopolysaccharide-mediated Signaling Pathway Interleukin-1 Beta Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Response To Lipid Regulation Of Toll-like Receptor Signaling Pathway Triglyceride Transport Plasma Lipoprotein Particle Clearance Low-density Lipoprotein Particle Clearance Response To Stilbenoid Toll-like Receptor TLR6:TLR2 Signaling Pathway Negative Regulation Of Protein Import Into Nucleus Lipoprotein Transport Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Protein-containing Complex Assembly Apoptotic Cell Clearance Neutrophil Degranulation Long-chain Fatty Acid Import Into Cell Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Peptidyl-tyrosine Phosphorylation Defense Response To Gram-positive Bacterium Intestinal Absorption Sensory Perception Of Taste Positive Regulation Of NF-kappaB Transcription Factor Activity Low-density Lipoprotein Particle Mediated Signaling Positive Regulation Of Phagocytosis, Engulfment Positive Regulation Of Macrophage Cytokine Production Positive Regulation Of ERK1 And ERK2 Cascade Cholesterol Import Response To Fatty Acid Response To Linoleic Acid Cellular Response To Lipopolysaccharide Cellular Response To Lipoteichoic Acid Cellular Response To Low-density Lipoprotein Particle Stimulus Cellular Response To Hydroperoxide Cellular Response To Diacyl Bacterial Lipopeptide Energy Homeostasis Regulation Of Action Potential Positive Regulation Of Cold-induced Thermogenesis Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Oxidised Low-density Lipoprotein Particle Clearance Amyloid-beta Clearance By Cellular Catabolic Process Positive Regulation Of NLRP3 Inflammasome Complex Assembly Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Amyloid-beta Amyloid Fibril Formation Lipid Transport Across Blood-brain Barrier Regulation Of Removal Of Superoxide Radicals Positive Regulation Of Blood Microparticle Formation	Cell-substrate Junction Assembly Integrin-mediated Signaling Pathway Ectodermal Cell Differentiation Positive Regulation Of Cell-substrate Adhesion Positive Regulation Of Neuron Projection Development Extracellular Matrix Organization Positive Regulation Of Cell Migration Hemidesmosome Assembly Cell-substrate Adhesion Nail Development Positive Regulation Of Phosphorylation Positive Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Skin Morphogenesis Positive Regulation Of Transcription By RNA Polymerase II Leukocyte Migration Cellular Response To Organic Cyclic Compound Cell-cell Adhesion Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways		Platelet degranulation Cross-presentation of particulate exogenous antigens (phagosomes) ER-Phagosome pathway MyD88:MAL(TIRAP) cascade initiated on plasma membrane Toll Like Receptor TLR6:TLR2 Cascade PPARA activates gene expression Scavenging by Class B Receptors Scavenging by Class B Receptors Transcriptional regulation of white adipocyte differentiation Intracellular metabolism of fatty acids regulates insulin secretion MyD88 deficiency (TLR2/4) IRAK4 deficiency (TLR2/4) Regulation of TLR by endogenous ligand Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Assembly of collagen fibrils and other multimeric structures Basigin interactions Integrin cell surface interactions Integrin cell surface interactions Laminin interactions Laminin interactions Syndecan interactions Type I hemidesmosome assembly
Drugs
Diseases			Epidermolysis bullosa, junctional, including: Epidermolysis bullosa, junctional, Herlitz type (JEB-H); Epidermolysis bullosa, junctional, non-Herlitz type (JEB-nH); Epidermolysis bullosa, junctional, with pyloric atresia (JEB-PA)
GWAS		Aspartate aminotransferase levels ( 29403010) Basophil count ( 32888494) Blood protein levels ( 30072576) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Electrocardiographic traits ( 32602732) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) HDL cholesterol ( 23726366 30275531) HDL cholesterol levels in current drinkers ( 30698716) HDL cholesterol levels x alcohol consumption (drinkers vs non-drinkers) interaction (2df) ( 30698716) HDL cholesterol levels x alcohol consumption (regular vs non-regular drinkers) interaction (2df) ( 30698716) Hemoglobin ( 32888494) High density lipoprotein cholesterol levels ( 29403010) Left ventricular mass ( 19454037) Mean corpuscular hemoglobin concentration ( 29403010) Mean corpuscular volume ( 32888494 27863252) Mean platelet volume ( 32888494 27863252) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Night sleep phenotypes ( 27126917) Platelet count ( 29403010 32888494 22423221 27863252) Plateletcrit ( 32888494) Red blood cell count ( 32888494 27863252) Red cell distribution width ( 32888494 28957414) Response to fenofibrate ( 22890011)	Alzheimer's disease biomarkers ( 23419831) Blood protein levels ( 28240269) Diabetic kidney disease ( 26305897) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Food allergy ( 29030101) Metabolite levels ( 23823483) Peanut allergy ( 29030101) Prostate cancer ( 31562322 19767753)
Interacting Genes		19 interacting genes: APOB APP CD9 CHRD COL1A1 COL1A2 FYN HSD11B1 ITGA2B ITGA6 ITGB1 ITGB3 LDLR LYN MATK SRC THBS1 VLDLR YES1	22 interacting genes: ADAM9 APP BIN1 CALM1 CANX CD151 CD36 CD63 CD82 COL17A1 GIPC1 GRB2 ITGB1 ITGB4 LGALS3BP PCSK5 PLEC PRKCD PXN RABIF RPSA TSPAN4
Entrez ID		948	3655
HPRD ID		01430	00945
Ensembl ID		ENSG00000135218	ENSG00000091409
Uniprot IDs		A4D1B1 B7Z6C3 E9PLT1 P16671	P23229
PDB IDs		5LGD
Enriched GO Terms of Interacting Partners?
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