MAP4K4 and KIF26B

Data Source:
BioGRID (two hybrid)

		MAP4K4	KIF26B
Description		mitogen-activated protein kinase kinase kinase kinase 4	kinesin family member 26B
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Focal Adhesion	Cytoplasm Kinesin Complex Microtubule
	Molecular Function	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Microtubule Motor Activity ATP Binding Microtubule Binding ATPase Activity
	Biological Process	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of ARF Protein Signal Transduction Activation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly	Microtubule-based Movement Positive Regulation Of Cell-cell Adhesion Establishment Of Cell Polarity Ureteric Bud Invasion
Pathways		Oxidative Stress Induced Senescence	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs		Fostamatinib
Diseases
GWAS		Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)	Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Daytime sleep phenotypes ( 27126917) Diverticular disease ( 30177863) Ischemic heart disease in rheumatoid arthritis ( 30251476) Metabolite levels ( 23823483) Prudent dietary pattern ( 28644415) Response to serotonin reuptake inhibitors in non-psychotic unipolar depression ( 26348319) Schizophrenia ( 23212062) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	7 interacting genes: CDK1 CDK2 CDK5 CDK6 MAP4K4 MX1 TRAF2
Entrez ID		9448	55083
HPRD ID		05235	13332
Ensembl ID		ENSG00000071054	ENSG00000162849
Uniprot IDs		B7Z3V5 O95819 V9HWH3	B7WPD9 Q2KJY2
PDB IDs		4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q
Enriched GO Terms of Interacting Partners?
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