MAP4K4 and KIF5A

Data Source:
BioGRID (two hybrid)

		MAP4K4	KIF5A
Description		mitogen-activated protein kinase kinase kinase kinase 4	kinesin family member 5A
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GO Annotations	Cellular Component	Cytoplasm Focal Adhesion	Cytosol Kinesin Complex Microtubule Membrane Dendrite Cytoplasm Perikaryon Synapse Perinuclear Region Of Cytoplasm Axon Cytoplasm
	Molecular Function	Creatine Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Microtubule Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity	Motor Activity Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATP-dependent Microtubule Motor Activity, Plus-end-directed ATPase Activity
	Biological Process	MAPK Cascade Negative Regulation Of Cell-matrix Adhesion Protein Phosphorylation Microvillus Assembly Positive Regulation Of Cell Migration Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of ARF Protein Signal Transduction Activation Of Protein Kinase Activity Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Regulation Of JNK Cascade Neuron Projection Morphogenesis Positive Regulation Of Keratinocyte Migration Positive Regulation Of Focal Adhesion Assembly Positive Regulation Of Focal Adhesion Disassembly	Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Microtubule-based Movement Chemical Synaptic Transmission Axon Guidance Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Cytoskeleton-dependent Intracellular Transport Synaptic Vesicle Transport Anterograde Dendritic Transport Of Neurotransmitter Receptor Complex Anterograde Axonal Protein Transport Retrograde Neuronal Dense Core Vesicle Transport
Pathways		Oxidative Stress Induced Senescence	MHC class II antigen presentation Insulin processing RHO GTPases activate KTN1 COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs		Fostamatinib
Diseases			Hereditary spastic paraplegia (SPG)
GWAS		Alzheimer's disease ( 30636644) Asthma ( 31619474) Asthma (time to onset) ( 27130862) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) White blood cell count ( 32888494)	Amyotrophic lateral sclerosis ( 29566793) Rheumatoid arthritis ( 24449572 18794853) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		18 interacting genes: BRCA1 CASP8 DOK1 GBP3 H2BC21 ITGB1 KIF26B KIF5A MAP3K7 NCK1 NME7 PPP1CA PPP1CC PRKCE RAP2A RASA1 SLC9A1 TBPL2	18 interacting genes: DTNB ITSN1 KCNE3 KIF5B KIF5C KLC3 MAP4K4 NCOA2 NDEL1 PIN1 RAPGEF2 SMN1 TK1 TP53BP2 TRIM55 TRIM63 TSG101 YAP1
Entrez ID		9448	3798
HPRD ID		05235	09108
Ensembl ID		ENSG00000071054	ENSG00000155980
Uniprot IDs		B7Z3V5 O95819 V9HWH3	Q12840
PDB IDs		4OBO 4OBP 4OBQ 4RVT 4U3Y 4U3Z 4U40 4U41 4U42 4U43 4U44 4U45 4ZK5 4ZP5 5DI1 5J95 5W5Q	4UXT 4UXY 4UY0
Enriched GO Terms of Interacting Partners?
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