PPP1R14A and CSNK1G2

Data Source:
HPRD (in vitro)

		PPP1R14A	CSNK1G2
Description		protein phosphatase 1 regulatory inhibitor subunit 14A	casein kinase 1 gamma 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol	Nucleus Cytoplasm Cytosol Plasma Membrane Cell Cortex Membrane
	Molecular Function	Protein Serine/threonine Phosphatase Inhibitor Activity	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	Negative Regulation Of Phosphoprotein Phosphatase Activity Regulation Of Phosphorylation	Protein Phosphorylation Endocytosis Signal Transduction Wnt Signaling Pathway Peptidyl-serine Phosphorylation Sphingolipid Biosynthetic Process Protein Autophosphorylation Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways		RHO GTPases activate PKNs	Sphingolipid de novo biosynthesis Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs			IC261 N-(2-Aminoethyl)-5-Chloroisoquinoline-8-Sulfonamide 5-iodotubercidin
Diseases
GWAS		Diverticular disease ( 30177863)	Body mass index ( 25673413) Coronary artery disease ( 29212778) Red cell distribution width ( 32888494 27863252)
Interacting Genes		16 interacting genes: APP CSNK1A1 CSNK1D CSNK1E CSNK1G1 CSNK1G2 CSNK1G3 DAPK1 PRKCA PRKCE PRKCG PRKCH PRKCZ PRKD1 PRNP YWHAZ	14 interacting genes: APP APPBP2 CERT1 DBNDD2 IRS4 KRTAP10-7 MTA1 NCK1 PER1 PPP1R14A RAP1GAP RUNDC3B SMAD3 WDCP
Entrez ID		94274	1455
HPRD ID		16291	03738
Ensembl ID		ENSG00000167641	ENSG00000133275
Uniprot IDs		Q96A00	P78368
PDB IDs			2C47
Enriched GO Terms of Interacting Partners?
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