MUC16 and MSLN

Data Source:
HPRD (in vitro)

		MUC16	MSLN
Description		mucin 16, cell surface associated	mesothelin
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Lumen Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Membrane Vesicle Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Stimulatory C-type Lectin Receptor Signaling Pathway Cell Adhesion O-glycan Processing	Cell Adhesion Cell-matrix Adhesion Pancreas Development Post-translational Protein Modification Cellular Protein Metabolic Process
Pathways		Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis	Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Oregovomab	Amatuximab
Diseases
GWAS		Asthma ( 30929738 32296059) Hepcidin/transferrin saturation ratio ( 27846281) Serum cancer antigen 125 levels ( 31666285) Tourette syndrome ( 30818990)	Body mass index ( 26426971) Serum cancer antigen 125 levels ( 31666285)
Interacting Genes		3 interacting genes: LGALS1 MSLN UBC	3 interacting genes: APPBP2 CPLANE2 MUC16
Entrez ID		94025	10232
HPRD ID		07548	03030
Ensembl ID		ENSG00000181143	ENSG00000102854
Uniprot IDs		B3KY81 Q8WXI7	Q13421
PDB IDs			4F3F
Enriched GO Terms of Interacting Partners?
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