MSLN and MUC16

Data Source:
HPRD (in vitro)

		MSLN	MUC16
Description		mesothelin	mucin 16, cell surface associated
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Golgi Apparatus Plasma Membrane Cell Surface Membrane Anchored Component Of Membrane	Golgi Lumen Plasma Membrane Integral Component Of Membrane Extrinsic Component Of Membrane Vesicle Extracellular Exosome
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Pancreas Development Post-translational Protein Modification Cellular Protein Metabolic Process	Stimulatory C-type Lectin Receptor Signaling Pathway Cell Adhesion O-glycan Processing
Pathways		Post-translational modification: synthesis of GPI-anchored proteins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation	Defective GALNT3 causes familial hyperphosphatemic tumoral calcinosis (HFTC) Defective C1GALT1C1 causes Tn polyagglutination syndrome (TNPS) Defective GALNT12 causes colorectal cancer 1 (CRCS1) Dectin-2 family O-linked glycosylation of mucins Termination of O-glycan biosynthesis
Drugs		Amatuximab	Oregovomab
Diseases
GWAS		Body mass index ( 26426971) Serum cancer antigen 125 levels ( 31666285)	Asthma ( 30929738 32296059) Hepcidin/transferrin saturation ratio ( 27846281) Serum cancer antigen 125 levels ( 31666285) Tourette syndrome ( 30818990)
Interacting Genes		3 interacting genes: APPBP2 CPLANE2 MUC16	3 interacting genes: LGALS1 MSLN UBC
Entrez ID		10232	94025
HPRD ID		03030	07548
Ensembl ID		ENSG00000102854	ENSG00000181143
Uniprot IDs		Q13421	B3KY81 Q8WXI7
PDB IDs		4F3F
Enriched GO Terms of Interacting Partners?
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