RECQL5 and TOP3A

Data Source:
HPRD (in vitro, in vivo)

		RECQL5	TOP3A
Description		RecQ like helicase 5	DNA topoisomerase III alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol RNA Polymerase II, Holoenzyme	Nucleus Nucleoplasm Chromosome Mitochondrial Matrix PML Body
	Molecular Function	RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	DNA Binding Single-stranded DNA Binding DNA Topoisomerase Activity DNA Topoisomerase Type I (single Strand Cut, ATP-independent) Activity Protein Binding Zinc Ion Binding
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Drug Cell Division Chromosome Separation Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	DNA Replication DNA Topological Change Mitochondrial DNA Metabolic Process Chromosome Separation Meiotic Cell Cycle Regulation Of Signal Transduction By P53 Class Mediator
Pathways			HDR through Single Strand Annealing (SSA) HDR through Homologous Recombination (HRR) Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Resolution of D-loop Structures through Holliday Junction Intermediates Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination
Drugs
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)	Systolic blood pressure ( 30224653)
Interacting Genes		20 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B	3 interacting genes: BLM RECQL5 TDRD3
Entrez ID		9400	7156
HPRD ID		04806	03145
Ensembl ID		ENSG00000108469	ENSG00000177302
Uniprot IDs		A0A024R8M9 A0A024R8S8 B3KQK2 O94762 Q8WYH5	B4DSJ0 Q13472
PDB IDs		4BK0 5LB3 5LB5 5LB8 5LBA	4CGY 4CHT
Enriched GO Terms of Interacting Partners?
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