RECQL5 and ALDH7A1

Data Source:
HPRD (two hybrid)

		RECQL5	ALDH7A1
Description		RecQ like helicase 5	aldehyde dehydrogenase 7 family member A1
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol RNA Polymerase II, Holoenzyme	Nucleus Mitochondrion Mitochondrial Matrix Cytosol Extracellular Exosome
	Molecular Function	RNA Polymerase II Complex Binding Nucleic Acid Binding DNA Helicase Activity ATP Binding Four-way Junction Helicase Activity 3'-5' DNA Helicase Activity	Aldehyde Dehydrogenase (NAD+) Activity L-aminoadipate-semialdehyde Dehydrogenase Activity Protein Binding Betaine-aldehyde Dehydrogenase Activity Glyceraldehyde-3-phosphate Dehydrogenase (NAD+) (non-phosphorylating) Activity
	Biological Process	Mitotic Cell Cycle Double-strand Break Repair Via Homologous Recombination DNA Metabolic Process DNA Replication DNA Unwinding Involved In DNA Replication DNA Repair DNA Recombination DNA Duplex Unwinding Negative Regulation Of Transcription Elongation From RNA Polymerase II Promoter Cellular Response To Drug Cell Division Chromosome Separation Cellular Response To Camptothecin Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Negative Regulation Of Double-strand Break Repair Via Homologous Recombination	Cellular Aldehyde Metabolic Process Lysine Catabolic Process Sensory Perception Of Sound Glycine Betaine Biosynthetic Process From Choline Choline Catabolic Process
Pathways			Choline catabolism Lysine catabolism
Drugs			NADH Artenimol
Diseases
GWAS		Deep white matter hyperintensities ( 32517579) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Periventricular white matter hyperintensities ( 32517579)	Colorectal cancer ( 30529582) Coronary artery calcified atherosclerotic plaque (90 or 130 HU threshold) in type 2 diabetes ( 29221444) Metabolite levels ( 23823483) Osteoporosis ( 20072603)
Interacting Genes		20 interacting genes: ADCY10P1 ALDH7A1 BNIPL CREB1 CUX1 DDX42 EEF1G ITGB3BP MAPK8IP1 MRE11 MTSS1 MUS81 NBN PLK1 RAD50 RAD51 STAMBP TIMP1 TOP3A TOP3B	5 interacting genes: APP EPS8 LCN2 MYG1 RECQL5
Entrez ID		9400	501
HPRD ID		04806	00124
Ensembl ID		ENSG00000108469	ENSG00000164904
Uniprot IDs		A0A024R8M9 A0A024R8S8 B3KQK2 O94762 Q8WYH5	P49419
PDB IDs		4BK0 5LB3 5LB5 5LB8 5LBA	2J6L 4X0T 4X0U 4ZUK 4ZUL 4ZVW 4ZVX 4ZVY 6O4B 6O4C 6O4D 6O4E 6O4F 6O4G 6O4H 6O4I 6O4K 6O4L 6U2X
Enriched GO Terms of Interacting Partners?
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