ADIPOQ and BSND

Data Source:
BioGRID (two hybrid)

		ADIPOQ	BSND
Description		adiponectin, C1Q and collagen domain containing	barttin CLCNK type accessory subunit beta
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Collagen-containing Extracellular Matrix	Cytoplasm Plasma Membrane Integral Component Of Plasma Membrane Basolateral Plasma Membrane Protein-containing Complex
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity	Chloride Channel Activity Protein Binding Chloride Channel Regulator Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Signal Transduction Response To Nutrient Circadian Rhythm Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Cellular Response To Drug Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Transporter Activity Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration	Chloride Transport Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways		AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation	Stimuli-sensing channels
Drugs
Diseases		Adiponectin deficiency	Bartter syndrome
GWAS		Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 21700879 26299439 20876611 20011104 22479202 20018283 19165155 24105470) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Copper levels ( 26025379)	Allergic rhinitis ( 25085501) Carotid intima media thickness x smoking interaction ( 32117412) Coronary artery disease ( 32469254 33020668) Medication use (HMG CoA reductase inhibitors) ( 31015401) Mitochondrial DNA copy number ( 30704525)
Interacting Genes		61 interacting genes: ADIPOR2 AMIGO1 AQP6 ASGR2 BCL2L13 BIK BNIP3L BSND BTNL9 CAMLG CCDC107 CD200R1 CD79A CDH13 CLDN9 CLEC10A CLEC2D CNR2 COQ9 CPLX4 CREB3L1 CYBC1 ERP29 FAM209A FASN FCGR1A FKBP7 FNDC9 GPR152 GPR42 HSD17B11 IFNGR2 KASH5 KCNK5 KEL MFF MFSD14B MFSD6 MRM1 MS4A3 MUC1 NEMP1 PEX12 PROKR2 PVR SCN3B SGTA SGTB SIGLEC12 SLC16A2 SLC22A23 SLC35C2 SLC35E3 SYAP1 SYNE4 TMEM179B TMEM237 TMEM35A TMPRSS2 TNFSF14 TRIM35	28 interacting genes: ADIPOQ APOL2 APP ARFIP1 BMP10 CDIPT CERT1 COL4A5 COL8A2 CSGALNACT2 CTSA ECPAS FATE1 GAD2 IGFBP5 JAGN1 MYG1 PBX3 PLSCR2 PTPN9 SLC30A8 SPG21 STX8 TBRG4 THAP4 TMEM60 VAMP3 ZFPL1
Entrez ID		9370	7809
HPRD ID		05671	05914
Ensembl ID		ENSG00000181092	ENSG00000162399
Uniprot IDs		A8K660 B2R773 Q15848	Q5VU50 Q8WZ55
PDB IDs		4DOU 6U66 6U6N
Enriched GO Terms of Interacting Partners?
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