ADIPOQ and SLC22A23

Data Source:
BioGRID (two hybrid)

		ADIPOQ	SLC22A23
Description		adiponectin, C1Q and collagen domain containing	solute carrier family 22 member 23
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Cell Surface Collagen-containing Extracellular Matrix	Integral Component Of Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Hormone Activity Extracellular Matrix Structural Constituent Protein Binding Sialic Acid Binding Identical Protein Binding Protein Homodimerization Activity	Protein Binding Transmembrane Transporter Activity
	Biological Process	Response To Hypoxia Positive Regulation Of Protein Phosphorylation Glucose Metabolic Process Generation Of Precursor Metabolites And Energy Fatty Acid Beta-oxidation Signal Transduction Response To Nutrient Circadian Rhythm Response To Bacterium Response To Sucrose Response To Glucose Positive Regulation Of Signal Transduction Gene Expression Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Positive Regulation Of Protein Kinase A Signaling Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of Cholesterol Efflux Regulation Of Glucose Metabolic Process Response To Activity Fatty Acid Oxidation Negative Regulation Of Cell Migration Negative Regulation Of Granulocyte Differentiation Negative Regulation Of Protein Autophosphorylation Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-8 Production Cellular Response To Insulin Stimulus Positive Regulation Of Myeloid Cell Apoptotic Process Negative Regulation Of Heterotypic Cell-cell Adhesion Low-density Lipoprotein Particle Clearance Response To Tumor Necrosis Factor Cellular Response To Drug Regulation Of Fatty Acid Biosynthetic Process Glucose Homeostasis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling Negative Regulation Of MAP Kinase Activity Response To Ethanol Negative Regulation Of Fat Cell Differentiation Negative Regulation Of Macrophage Differentiation Negative Regulation Of Gluconeogenesis Negative Regulation Of Blood Pressure Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Fatty Acid Metabolic Process Positive Regulation Of Glucose Import Negative Regulation Of Hormone Secretion Negative Regulation Of Inflammatory Response Positive Regulation Of Peptidyl-tyrosine Phosphorylation Negative Regulation Of Phagocytosis Negative Regulation Of Synaptic Transmission Brown Fat Cell Differentiation Response To Glucocorticoid Negative Regulation Of ERK1 And ERK2 Cascade Response To Linoleic Acid Detection Of Oxidative Stress Cellular Response To CAMP Positive Regulation Of Monocyte Chemotactic Protein-1 Production Cellular Response To Epinephrine Stimulus Protein Localization To Plasma Membrane Negative Regulation Of Intracellular Protein Transport Positive Regulation Of Lipid Transporter Activity Positive Regulation Of Cold-induced Thermogenesis Negative Regulation Of Cold-induced Thermogenesis Negative Regulation Of Receptor Binding Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Vascular Associated Smooth Muscle Cell Migration Negative Regulation Of Low-density Lipoprotein Receptor Activity Negative Regulation Of DNA Biosynthetic Process Positive Regulation Of Glycogen (starch) Synthase Activity Positive Regulation Of Metanephric Glomerular Visceral Epithelial Cell Development Positive Regulation Of CAMP-dependent Protein Kinase Activity Positive Regulation Of Renal Albumin Absorption Negative Regulation Of Platelet-derived Growth Factor Receptor-alpha Signaling Pathway Negative Regulation Of Metanephric Mesenchymal Cell Migration	Ion Transport Transmembrane Transport
Pathways		AMPK inhibits chREBP transcriptional activation activity AMPK inhibits chREBP transcriptional activation activity Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases		Adiponectin deficiency
GWAS		Activated partial thromboplastin time ( 22703881) Adiponectin levels ( 21700879 26299439 20876611 20011104 22479202 20018283 19165155 24105470) Adiponectin levels (BMI-adjusted) ( 26299439) Adiponectin levels in pregnancy ( 28317342) Copper levels ( 26025379)	Antipsychotic drug-induced QTc interval prolongation ( 20921969) Bone mineral density (femoral neck) in inflammatory bowel disease ( 29603369) Cognitive ability ( 29186694) Cognitive ability (MTAG) ( 29186694) Drug-induced Stevens-Johnson syndrome or toxic epidermal necrolysis (SJS/TEN) ( 21221126) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Fasting insulin (dietary factor interaction) ( 24204828) General cognitive ability ( 29844566) Homeostasis model assessment of insulin resistance (dietary factor interaction) ( 24204828) Household income (MTAG) ( 31844048) Intelligence (MTAG) ( 29326435) Mean platelet volume ( 32888494 27863252) Nicotine dependence ( 28440896) Obesity-related traits ( 23251661) Primary biliary cholangitis ( 28425483) Red cell distribution width ( 32888494 27863252 28957414) Refractive error ( 32231278) Survival in rectal cancer ( 25866641)
Interacting Genes		61 interacting genes: ADIPOR2 AMIGO1 AQP6 ASGR2 BCL2L13 BIK BNIP3L BSND BTNL9 CAMLG CCDC107 CD200R1 CD79A CDH13 CLDN9 CLEC10A CLEC2D CNR2 COQ9 CPLX4 CREB3L1 CYBC1 ERP29 FAM209A FASN FCGR1A FKBP7 FNDC9 GPR152 GPR42 HSD17B11 IFNGR2 KASH5 KCNK5 KEL MFF MFSD14B MFSD6 MRM1 MS4A3 MUC1 NEMP1 PEX12 PROKR2 PVR SCN3B SGTA SGTB SIGLEC12 SLC16A2 SLC22A23 SLC35C2 SLC35E3 SYAP1 SYNE4 TMEM179B TMEM237 TMEM35A TMPRSS2 TNFSF14 TRIM35	17 interacting genes: ADAM33 ADIPOQ CBLIF CLCA4 CLN6 CNIH1 ERMP1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MEOX2 NOTCH2NLA OLFM4 PSMA3 PTTG1IP UPK2 WFDC2
Entrez ID		9370	63027
HPRD ID		05671	12904
Ensembl ID		ENSG00000181092	ENSG00000137266
Uniprot IDs		A8K660 B2R773 Q15848	A1A5C7 Q9UFY2
PDB IDs		4DOU 6U66 6U6N
Enriched GO Terms of Interacting Partners?
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