TRIP13 and PLK3

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		TRIP13	PLK3
Description		thyroid hormone receptor interactor 13	polo like kinase 3
Image
GO Annotations	Cellular Component	Male Germ Cell Nucleus Nucleus Chromosome	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body
	Molecular Function	Transcription Coregulator Activity Protein Binding ATP Binding ATPase Activity Identical Protein Binding	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding
	Biological Process	Oocyte Maturation Double-strand Break Repair Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II Mitotic Spindle Assembly Checkpoint Synaptonemal Complex Assembly Reciprocal Meiotic Recombination Male Meiosis I Female Meiosis I Spermatogenesis Spermatid Development Oogenesis Meiotic Recombination Checkpoint	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia
Pathways			TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation
Drugs			Fostamatinib
Diseases
GWAS		Pancreatic cancer ( 25086665)
Interacting Genes		112 interacting genes: ADAM15 AMDHD2 ANKRD10 ARL11 ARSA ASB13 BUB1B C11orf54 C19orf54 C4orf33 CARD14 CD99 CDC20 CDIN1 CEP170B CFP CLIP4 COMT CRMP1 CRYBA2 CYB5R2 DCTN3 DDAH2 DIP2A DPYSL4 DTX2 EEF2KMT FBLN5 FBXO8 FNDC3B GALT GLYCTK GPRIN2 GPSM1 HDHD3 IGFN1 IL2RB INCA1 INTS11 KRTAP12-1 KRTAP12-2 KRTAP12-4 KRTAP26-1 KRTAP3-2 KRTAP6-1 KRTAP6-2 KYAT1 LASP1 LNX1 LOXL4 LRR1 LRRC61 M1AP MAD2L1 MAD2L1BP MBLAC1 MEAK7 METTL15 MGAT5B MORN3 MPPED2 MVP MYEOV NIF3L1 NME4 NTAQ1 PARP11 PAX9 PBLD PCMTD2 PCSK5 PELI1 PLAC8 PLK3 PLSCR3 PLSCR4 POLR2L PPP2CA PRKAA2 PRKN PRR13 PSMB8 QARS1 RBPMS RHOXF2 RNF4 SCP2 SDCBP SEC24A SELENBP1 SEMA3B SEMA4G SHARPIN SIGLEC5 SMUG1 SPRYD7 SSC4D STAMBP STAMBPL1 SUMO2 TENT5B TEX37 THRB TINAGL1 TNRC6A TPT1 UBE2I VDR VENTX ZMYM5 ZNF34 ZNF655	24 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF PLK1 POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1
Entrez ID		9319	1263
HPRD ID		05145	04222
Ensembl ID		ENSG00000071539	ENSG00000173846
Uniprot IDs		Q15645	Q9H4B4
PDB IDs		5VQ9 5VQA 5WC2 6F0X 6LK0	4B6L
Enriched GO Terms of Interacting Partners?
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