PLK3 and VRK1

Data Source:
HPRD (in vitro, in vivo)

		PLK3	VRK1
Description		polo like kinase 3	VRK serine/threonine kinase 1
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GO Annotations	Cellular Component	Spindle Pole Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Centrosome Dendrite Neuronal Cell Body	Nucleus Nucleoplasm Nucleolus Cytoplasm Golgi Stack Spindle Cytosol
	Molecular Function	P53 Binding Protein Serine/threonine Kinase Activity Protein Binding ATP Binding	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein Kinase Binding Nucleosomal Histone Binding Histone Kinase Activity (H3-S10 Specific) Histone Kinase Activity (H3-T3 Specific) Protein Serine Kinase Activity Protein Threonine Kinase Activity
	Biological Process	G1/S Transition Of Mitotic Cell Cycle G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Transcription By RNA Polymerase II Mitotic Cell Cycle Response To Reactive Oxygen Species Protein Phosphorylation Apoptotic Process Response To Osmotic Stress Cellular Response To DNA Damage Stimulus DNA Damage Response, Signal Transduction By P53 Class Mediator Resulting In Cell Cycle Arrest Mitotic Cell Cycle Checkpoint Endomitotic Cell Cycle Response To Radiation Cytoplasmic Microtubule Organization Regulation Of Cytokinesis Negative Regulation Of Apoptotic Process Protein Kinase B Signaling Mitotic G1/S Transition Checkpoint Regulation Of Cell Division Golgi Disassembly Positive Regulation Of Intracellular Protein Transport Regulation Of Signal Transduction By P53 Class Mediator Positive Regulation Of Chaperone-mediated Autophagy Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Involved In Cellular Response To Hypoxia	Protein Phosphorylation Mitotic Nuclear Envelope Disassembly Mitotic Nuclear Envelope Reassembly Peptidyl-serine Phosphorylation Histone H3-S10 Phosphorylation Protein Autophosphorylation Cell Division Histone H3-T3 Phosphorylation Golgi Disassembly
Pathways		TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain Regulation of TP53 Activity through Phosphorylation	Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation
Drugs		Fostamatinib
Diseases			Pontocerebellar hypoplasia
GWAS			Bone ultrasound measurement (velocity of sound) ( 28472463) Carboplatin disposition in epthelial ovarian cancer ( 29367611) Cognitive function ( 24684796) Copper levels ( 26025379) Fractures (paediatric) ( 32742401) Metabolite levels ( 23823483) Neutrophil count ( 21507922) Night sleep phenotypes ( 27126917) Staphylococcus aureus infection ( 24847357)
Interacting Genes		24 interacting genes: AURKA BCL2L1 CDC25C CENPU CHEK2 CIB1 HIF1A LSM5 MAP2K1 MAPK1 MFF PLK1 POU2F1 PPM1A RAD52 RNF141 RRM2 SLX4 SNCA SNCB TNS2 TP53 TRIP13 VRK1	6 interacting genes: H2BC21 H3C14 NBN PLK3 SRPK2 TP53
Entrez ID		1263	7443
HPRD ID		04222	03701
Ensembl ID		ENSG00000173846	ENSG00000100749
Uniprot IDs		Q9H4B4	Q99986
PDB IDs		4B6L	2KTY 2KUL 2LAV 2RSV 3OP5 5UKF 5UVF 6AC9 6BP0 6BRU 6BTW 6BU6 6CFM 6CMM 6CNX 6CQH 6CSW 6DD4 6NPN 6VZH
Enriched GO Terms of Interacting Partners?
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