ASIC3 and LIN7B

Data Source:
BioGRID (affinity chromatography technology, two hybrid)
HPRD (two hybrid, in vivo)

		ASIC3	LIN7B
Description		acid sensing ion channel subunit 3	lin-7 homolog B, crumbs cell polarity complex component
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Perinuclear Region Of Cytoplasm	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane
	Molecular Function	Cation Channel Activity Sodium Channel Activity Ligand-gated Sodium Channel Activity Enterobactin Transmembrane Transporter Activity Acid-sensing Ion Channel Activity	Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding
	Biological Process	Signal Transduction Sensory Perception Response To Heat Response To Acidic PH Ion Transmembrane Transport Sodium Ion Transmembrane Transport Enterobactin Transport Sensory Perception Of Sour Taste Detection Of Temperature Stimulus Involved In Sensory Perception Of Pain Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Detection Of Chemical Stimulus Involved In Sensory Perception Of Pain	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane
Pathways		Stimuli-sensing channels	Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors
Drugs		Agmatine
Diseases
GWAS		Eyebrow thickness ( 26926045)
Interacting Genes		9 interacting genes: ASIC2 CSNK2A1 DLG4 GOPC LIN7B MAGI1 PATJ PRKACA STOM	22 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP2 MPP3 MPP7 NTAQ1 PALS1 PALS2 PSMB1 TCEANC TRAPPC12
Entrez ID		9311	64130
HPRD ID		10626	10040
Ensembl ID		ENSG00000213199	ENSG00000104863
Uniprot IDs		A0A090N7X8 A0A090N8Q1 A0A090N8Z6 Q9UHC3	Q9HAP6
PDB IDs			2DKR
Enriched GO Terms of Interacting Partners?
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