LIN7B and KCNJ4

Data Source:
HPRD (in vitro, two hybrid, in vivo)

		LIN7B	KCNJ4
Description		lin-7 homolog B, crumbs cell polarity complex component	potassium inwardly rectifying channel subfamily J member 4
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GO Annotations	Cellular Component	Plasma Membrane Cell-cell Junction Bicellular Tight Junction Basolateral Plasma Membrane Synapse MPP7-DLG1-LIN7 Complex Presynapse Postsynaptic Density Membrane	Plasma Membrane Voltage-gated Potassium Channel Complex Basolateral Plasma Membrane Cytoplasmic Vesicle Membrane Postsynaptic Membrane
	Molecular Function	Protein Binding Protein Domain Specific Binding PDZ Domain Binding L27 Domain Binding	Inward Rectifier Potassium Channel Activity Protein Binding PDZ Domain Binding
	Biological Process	Exocytosis Neurotransmitter Secretion Protein Transport Maintenance Of Epithelial Cell Apical/basal Polarity Protein Localization To Basolateral Plasma Membrane	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Cardiac Conduction Potassium Ion Import Across Plasma Membrane
Pathways		Dopamine Neurotransmitter Release Cycle RHO GTPases Activate Rhotekin and Rhophilins Neurexins and neuroligins Assembly and cell surface presentation of NMDA receptors	Activation of G protein gated Potassium channels Classical Kir channels Phase 4 - resting membrane potential Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ranolazine Miconazole Carvedilol Dronedarone
Diseases
GWAS			Automobile speeding propensity ( 30643258) Chronotype ( 30696823) Conotruncal heart defects ( 24800985) TPE interval (resting) ( 32386560)
Interacting Genes		22 interacting genes: ABCA1 APBA1 ASIC3 BAIAP2 CASK DLG4 ENKD1 GNG13 GRIK2 GRIN2B KCNJ12 KCNJ4 MAK16 MPP2 MPP3 MPP7 NTAQ1 PALS1 PALS2 PSMB1 TCEANC TRAPPC12	11 interacting genes: CASK DLG1 DLG2 DLG4 GNGT2 GPR35 IL16 KCNJ2 LIN7B PRKCD SNTA1
Entrez ID		64130	3761
HPRD ID		10040	02738
Ensembl ID		ENSG00000104863	ENSG00000168135
Uniprot IDs		Q9HAP6	A0A024R1L8 P48050 Q58F07
PDB IDs		2DKR	3GJ9
Enriched GO Terms of Interacting Partners?
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