ATXN3L and RFFL

Data Source:
BioGRID (enzymatic study)

		ATXN3L	RFFL
Description		ataxin 3 like	ring finger and FYVE like domain containing E3 ubiquitin protein ligase
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GO Annotations	Cellular Component	Nucleus Cytosol	Golgi Membrane Nucleoplasm Cytoplasm Lysosome Cytosol Plasma Membrane Endosome Membrane Membrane Recycling Endosome Membrane
	Molecular Function	Thiol-dependent Ubiquitin-specific Protease Activity Cysteine-type Peptidase Activity	Protease Binding P53 Binding Protein Binding Protein Kinase Binding Ubiquitin Protein Ligase Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Protein Deubiquitination Protein Phosphopantetheinylation	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process Regulation Of Fibroblast Migration Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of TOR Signaling Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Execution Phase Of Apoptosis
Pathways		Josephin domain DUBs	Regulation of TP53 Degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Night sleep phenotypes ( 27126917) QT interval ( 19305408)
Interacting Genes		8 interacting genes: KLF5 PJA1 RFFL TRIM54 TRIM55 TRIM63 UBC USP28	21 interacting genes: ATXN3 ATXN3L EHD1 ESPL1 MICALL1 OPTN OTUB1 OTUB2 RAB11FIP1 SFN STAM UBE2D1 UBE2D2 UBE2D3 UBE2G2 UBE2N UBE2V2 UCHL5 USP28 USP5 USP7
Entrez ID		92552	117584
HPRD ID		19697	11489
Ensembl ID		ENSG00000123594	ENSG00000092871
Uniprot IDs		B4DYC7 Q9H3M9	Q8WZ73
PDB IDs		3O65	1Y02
Enriched GO Terms of Interacting Partners?
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