MAGI1 and RASA1

Data Source:
HPRD (in vitro)

		MAGI1	RASA1
Description		membrane associated guanylate kinase, WW and PDZ domain containing 1	RAS p21 protein activator 1
Image
GO Annotations	Cellular Component	Nucleoplasm Nucleolus Cytoplasm Plasma Membrane Cell-cell Junction Adherens Junction Bicellular Tight Junction Cell Junction Cell Projection Cell Periphery	Ruffle Cytoplasm Cytosol Plasma Membrane
	Molecular Function	Protein Binding ATP Binding Protein C-terminus Binding Alpha-actinin Binding Molecular Adaptor Activity	Phosphotyrosine Residue Binding GTPase Activity GTPase Activator Activity Signaling Receptor Binding Protein Binding Potassium Channel Inhibitor Activity GTPase Binding
	Biological Process	Cell Adhesion Signal Transduction Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell-cell Adhesion Protein-containing Complex Assembly	MAPK Cascade Mitotic Cytokinesis Vasculogenesis Negative Regulation Of Cell-matrix Adhesion Negative Regulation Of Cell Adhesion Signal Transduction Regulation Of Cell Shape Regulation Of Actin Filament Polymerization Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of GTPase Activity Negative Regulation Of Ras Protein Signal Transduction Ephrin Receptor Signaling Pathway Blood Vessel Morphogenesis Regulation Of RNA Metabolic Process
Pathways			Downstream signal transduction EPHB-mediated forward signaling EPHB-mediated forward signaling VEGFR2 mediated cell proliferation Regulation of RAS by GAPs PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases
Drugs
Diseases			RASA1-related disorders, including: Parkes-Weber slndrome; Capillary malformation-arteriovenous malformation (CM-AVM); Arteriovenous fistula (AVF)
GWAS		Adolescent idiopathic scoliosis ( 28334814) Asthma ( 27611488) Asthma (childhood onset) ( 27611488) Body size at age 10 ( 32376654) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cobalt levels ( 26025379) Coronary artery calcified atherosclerotic plaque score in type 2 diabetes ( 29221444) Cortical surface area (MOSTest) ( 32665545) Crohn's disease-related phenotypes ( 25557950) Homeostasis model assessment of beta-cell function (dietary factor interaction) ( 24204828) Knee osteoarthritis ( 28916551) Neurociticism ( 29500382) Neuroticism ( 25993607) Nicotine dependence symptom count ( 25555482) Ocular sarcoidosis ( 32141793) Ocular sarcoidosis in sarcoidosis ( 32141793) Post bronchodilator FEV1/FVC ratio ( 26634245) PR interval ( 23534349) Pre-treatment viral load in HIV-1 infection ( 31219150) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Chronotype ( 30696823) Macular thickness ( 30535121) Major depressive disorder ( 23377640) Openness ( 21173776) Prostate cancer aggressiveness ( 25939597) Type 2 diabetes ( 30297969)
Interacting Genes		25 interacting genes: ACTN4 ADGRB1 AMOT ASIC3 ATN1 CLCN5 CRHR1 CTNNB1 DAG1 GBP2 IGSF5 IL6R LRP2 NET1 RAC1 RASA1 RASL11B RPS6KA1 RPS6KA2 RPS6KA3 SYNPO TFAP2A TP53BP2 WBP1 WBP2	94 interacting genes: ABL1 AFAP1L2 ANXA6 APC APP AR ARHGAP1 ARHGAP5 AURKA AURKB BBS10 BCL10 BCR BIRC5 BMPR1A BUB1 CASP3 CASP7 CAV2 CD5 CDKN2A CSF1R CSK DCC DLC1 DNAJA3 DOK1 DOK2 DOK4 EGFR EIF1 EPHA2 EPHB2 EPHB3 ERBB2 ERBB3 ERBB4 EZH2 FES FGFR1 G3BP1 GAB1 GMCL1 GRB2 HCK HRAS HSPD1 HTT IGF1R INSR KDR KHDRBS1 KIT LCK LYN MAGI1 MAP4K4 MET MLH3 NCK1 NRAS NTRK1 OLIG1 PAG1 PDE6D PDGFRB PIK3R1 PMS2 PTK2B PTPRC PTPRJ PXN RAB5A RACK1 RAP1A RB1 SERPINA4 SHC1 SLC9A2 SMAD2 SOCS3 SPSB1 SRC STAU1 STK11 SYK SYN1 TRMT2A WWP1 WWP2 XRCC6 YES1 ZAP70 ZNF579
Entrez ID		9223	5921
HPRD ID		04020	00745
Ensembl ID		ENSG00000151276	ENSG00000145715
Uniprot IDs		Q96QZ7	P20936 Q59GK3
PDB IDs		1WBP 2KPK 2KPL 2Q9V 2R4H 2YSD 2YSE 2ZAJ 3BPU 5N7D 5N7F 5N7G 6TWU 6TWX 6TWY	1WER 1WQ1 2GQI 2GSB 2J05 2J06 2M51 4FSS 6PXB 6PXC 6WAX 6WAY
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?