NOLC1 and POLR1A

Data Source:
HPRD (in vivo, in vitro)

		NOLC1	POLR1A
Description		nucleolar and coiled-body phosphoprotein 1	RNA polymerase I subunit A
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleoplasm Nucleolus Cytoplasm Cajal Body Box C/D RNP Complex Box H/ACA SnoRNP Complex	Nucleoplasm Chromosome RNA Polymerase I Complex
	Molecular Function	DNA Binding DNA-binding Transcription Factor Activity RNA Binding Protein Binding ATP Binding GTP Binding Transcription Factor Binding Nuclear Localization Sequence Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Box C/D RNA Binding Box H/ACA SnoRNA Binding Protein Heterodimerization Activity Box C/D SnoRNP Complex Binding Box H/ACA SnoRNP Complex Binding	RNA Polymerase I Activity DNA Binding Chromatin Binding DNA-directed 5'-3' RNA Polymerase Activity Protein Binding Zinc Ion Binding
	Biological Process	Mitotic Cell Cycle RRNA Processing Regulation Of Translation Response To Osmotic Stress Nucleolus Organization Positive Regulation Of Cell Population Proliferation Neural Crest Formation Neural Crest Cell Development Box H/ACA RNA Metabolic Process Regulation Of Protein Import Into Nucleus Positive Regulation Of Transcription, DNA-templated	Transcription Initiation From RNA Polymerase I Promoter Transcription Elongation From RNA Polymerase I Promoter Termination Of RNA Polymerase I Transcription Positive Regulation Of Gene Expression, Epigenetic Negative Regulation Of Protein Localization To Nucleolus
Pathways			NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression RNA Polymerase I Transcription Initiation RNA Polymerase I Transcription Initiation RNA Polymerase I Promoter Escape RNA Polymerase I Transcription Termination
Drugs		Doxorubicin
Diseases
GWAS		Triglyceride levels ( 32203549)	Facial emotion recognition (sad faces) ( 28608620)
Interacting Genes		16 interacting genes: APP CEBPB COIL CSNK2A1 CSNK2B E2F4 ERG GTF2B KBTBD8 MDM2 POLR1A PRKACA SRPK2 USP4 YWHAG YWHAQ	10 interacting genes: ANP32B DYDC2 MEOX2 NFKBIB NOLC1 POLR1E PTEN REL RRN3 TCF4
Entrez ID		9221	25885
HPRD ID		03864	10161
Ensembl ID		ENSG00000166197	ENSG00000068654
Uniprot IDs		B2RAU8 Q14978 Q96J17	O95602
PDB IDs
Enriched GO Terms of Interacting Partners?
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