LONRF1 and TRIM8

Data Source:
BioGRID (two hybrid)

		LONRF1	TRIM8
Description		LON peptidase N-terminal domain and ring finger 1	tripartite motif containing 8
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	Cytosol PML Body
	Molecular Function	Protein Binding Metal Ion Binding	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity
	Biological Process	Protein Polyubiquitination	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell
Pathways		Antigen processing: Ubiquitination & Proteasome degradation	Interferon gamma signaling
Drugs
Diseases
GWAS		Apolipoprotein A1 levels ( 32203549) Colorectal cancer (diet interaction) ( 24743840) HDL cholesterol levels ( 32203549)	anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		96 interacting genes: ADAMTSL4 ALAS1 AP2B1 ATG9A AVPI1 BHLHB9 BRCA1 BYSL C4orf17 CALCOCO2 CBLL2 CDKN2D CFP CRX CYSRT1 DVL3 EFHC2 FLACC1 GABPB2 GORASP1 GORASP2 HLX HOXA1 HSPB1 IHO1 IKZF2 IKZF3 IQCF2 KAT5 KATNBL1 KCTD21 KCTD9 KHDC1 KRT31 KRT35 KRT75 KRTAP1-3 KRTAP13-1 KRTAP13-3 KRTAP19-6 KRTAP19-7 KRTAP3-3 KRTAP6-1 LGALS9B LHX2 LHX4 LNX1 MAGED1 MGAT5B MID2 MRPL38 MTMR3 MYOZ3 NR4A1 NTAQ1 OOEP PATZ1 PAX5 PAX6 PAX8 PICK1 PLSCR1 POU6F2 PPP1R3C PRDM16 PRDM6 PRR35 PSMA1 RBPMS RIMBP3C RPRD1A SFN SLU7 SPRY2 STAU1 STX11 TASOR2 TBX19 TRAF2 TRIM27 TRIM42 TRIM8 TRIM9 UBE2I UBE2L6 UCHL3 USP2 VGLL1 WDR83 XIAP YPEL3 ZFP90 ZNF426 ZNF653 ZNF774 ZNHIT2	63 interacting genes: BRAP CATSPER1 CBL CCNH DCUN1D1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1
Entrez ID		91694	81603
HPRD ID		08674	06934
Ensembl ID		ENSG00000154359	ENSG00000171206
Uniprot IDs		Q17RB8	Q9BZR9
PDB IDs
Enriched GO Terms of Interacting Partners?
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