TRIM8 and RNF113A

Data Source:
BioGRID (two hybrid)

		TRIM8	RNF113A
Description		tripartite motif containing 8	ring finger protein 113A
Image		No pdb structure
GO Annotations	Cellular Component	Cytosol PML Body	Nucleus Nucleoplasm U2-type Spliceosomal Complex Nuclear Speck U2-type Precatalytic Spliceosome
	Molecular Function	Transcription Coactivator Activity Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Protein Homodimerization Activity	Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Positive Regulation Of Autophagy Protein Ubiquitination Stem Cell Population Maintenance Negative Regulation Of Viral Transcription Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Innate Immune Response Positive Regulation Of Transcription, DNA-templated Negative Regulation Of Viral Entry Into Host Cell Positive Regulation Of DNA-binding Transcription Factor Activity Positive Regulation Of NF-kappaB Transcription Factor Activity Interferon-gamma-mediated Signaling Pathway Positive Regulation Of Protein Localization To Nucleus Negative Regulation Of Viral Release From Host Cell	MRNA Splicing, Via Spliceosome DNA Repair Protein Ubiquitination Isopeptide Cross-linking Via N6-glycyl-L-lysine SnoRNA Splicing Negative Regulation Of Chemokine-mediated Signaling Pathway
Pathways		Interferon gamma signaling
Drugs
Diseases
GWAS		anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Autism spectrum disorder or schizophrenia ( 28540026) Body mass index ( 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Brain morphology (MOSTest) ( 32665545) Feeling nervous ( 29500382) Prostate cancer ( 23535732) Pulse pressure ( 30578418) Refractive error ( 32231278) Schizophrenia ( 25056061 30285260) Smoking status (ever vs never smokers) ( 30643258) Ulcerative colitis ( 26192919) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		63 interacting genes: BRAP CATSPER1 CBL CCNH DCUN1D1 FAM124B HOXA1 ITSN1 LNX1 LONRF1 MAGEC2 MKRN3 MSL2 MTURN NUDT10 OTUB2 PCGF5 RAD18 RAD23A RC3H2 RCHY1 RNF111 RNF113A RNF138 RNF141 RNF168 RNF181 RNF41 RNF7 SIAH1 SOCS1 TICAM1 TNFAIP3 TNIP3 TNPO2 TNS2 TRAF5 TRIM15 TRIM2 TRIM21 TRIM24 TRIM25 TRIM39 TRIM43 TRIM47 TRIM9 UBASH3A UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2L6 UBE2V1 UBE2W UBXN7 UHRF2 USP2 USP21 USP39 USP5 USP7 XIAP YOD1	8 interacting genes: CCAR1 CXCR4 ILF3 RBM39 SNRNP200 TERF2 TRIM8 UBE2U
Entrez ID		81603	7737
HPRD ID		06934	06760
Ensembl ID		ENSG00000171206	ENSG00000125352
Uniprot IDs		Q9BZR9	O15541
PDB IDs			5Z56 5Z58 6FF4 6FF7
Enriched GO Terms of Interacting Partners?
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