CD3D and KCNA3

Data Source:
BioGRID (fluorescent resonance energy transfer)

		CD3D	KCNA3
Description		CD3d molecule	potassium voltage-gated channel subfamily A member 3
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane External Side Of Plasma Membrane Integral Component Of Membrane Clathrin-coated Vesicle Membrane T Cell Receptor Complex Alpha-beta T Cell Receptor Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Integral Component Of Membrane Axon Calyx Of Held Membrane Raft Glutamatergic Synapse Integral Component Of Postsynaptic Membrane Integral Component Of Presynaptic Membrane
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Identical Protein Binding Protein Heterodimerization Activity	Voltage-gated Ion Channel Activity Voltage-gated Potassium Channel Activity Delayed Rectifier Potassium Channel Activity Protein Binding Outward Rectifier Potassium Channel Activity
	Biological Process	Adaptive Immune Response Cell Surface Receptor Signaling Pathway Positive Thymic T Cell Selection Regulation Of Immune Response T Cell Receptor Signaling Pathway Membrane Organization	Potassium Ion Transport Regulation Of Ion Transmembrane Transport Protein Homooligomerization Potassium Ion Transmembrane Transport
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Downstream TCR signaling Phosphorylation of CD3 and TCR zeta chains Translocation of ZAP-70 to Immunological synapse Generation of second messenger molecules PD-1 signaling Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis	Voltage gated Potassium channels
Drugs		Muromonab Blinatumomab	Enflurane Clofazimine Promethazine Miconazole Dalfampridine
Diseases		T-B+Severe combined immunodeficiencies (SCIDs), including the following eight diseases: X-linked SCID; Janus kinase-3 (Jak3) deficiency; IL-7 receptor alpha (IL7R alpha) deficiency; IL-2 receptor alpha (IL2R alpha) deficiency; CD45 deficiency; CD3 deficiency; Winged Helix Nude (WHN) deficiency; Immunodeficiency with thynoma
GWAS		Pulse pressure ( 27841878)	Acute lymphoblastic leukemia (childhood) ( 22076464)
Interacting Genes		12 interacting genes: AP2M1 CANX CD247 CD3E CD3G CD8A CD8B HERPUD1 KCNA3 SGTB TRA TRB	10 interacting genes: BAX CAV1 CD3D DEFB4A DLG1 DLG4 DOLK IL16 KCNA1 KCNA2
Entrez ID		915	3738
HPRD ID		01730	15937
Ensembl ID		ENSG00000167286	ENSG00000177272
Uniprot IDs		B0YIY4 P04234	P22001
PDB IDs		1XIW 6JXR	4BGC
Enriched GO Terms of Interacting Partners?
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