PRPF3 and PIP4K2B

Data Source:
BioGRID (two hybrid)

		PRPF3	PIP4K2B
Description		pre-mRNA processing factor 3	phosphatidylinositol-5-phosphate 4-kinase type 2 beta
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Spliceosomal Complex Cytosol Cajal Body Nuclear Speck U4/U6 X U5 Tri-snRNP Complex U2-type Precatalytic Spliceosome	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane
	Molecular Function	RNA Binding Protein Binding Identical Protein Binding	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity
	Biological Process	Spliceosomal Tri-snRNP Complex Assembly RNA Splicing, Via Transesterification Reactions MRNA Splicing, Via Spliceosome MRNA Processing RNA Splicing	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly
Pathways		mRNA Splicing - Major Pathway	Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus
Drugs			Fostamatinib
Diseases		Retinitis pigmentosa (RP)
GWAS		Ambidextrousness ( 32989287) Blood protein levels ( 28240269) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronotype ( 27494321) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (min-P) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Low density lipoprotein cholesterol levels ( 30498476) Morning person ( 30696823) Morning vs. evening chronotype ( 27494321) Platelet count ( 32888494 27863252) Plateletcrit ( 27863252) Refractive error ( 32231278) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) White blood cell count ( 32888494)	Height ( 28552196 20881960 31562340)
Interacting Genes		52 interacting genes: BRCA1 CARD10 CASK CCDC125 CCDC136 CCDC85B CDC5L CEP70 CTNNBL1 DPY30 DVL2 DVL3 FAM9B FCHO1 FRA10AC1 GOLGA2 GPRASP2 GTPBP3 HSF2BP LZTS1 MAPRE1 MID2 NACC1 NAV2 NINL NKAP NKAPD1 OSBPL3 PCBP1 PHC2 PIP4K2B PRPF31 PSMD3 RABEP1 RBM39 RNF151 SART3 SHKBP1 SNIP1 SNRNP200 SSX2IP TRIM39 TSPYL1 TXLNA U2AF2 USP4 WBP4 ZBTB8A ZCCHC10 ZFPM2 ZGPAT ZRANB1	17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131
Entrez ID		9129	8396
HPRD ID		07389	04463
Ensembl ID		ENSG00000117360	ENSG00000276293
Uniprot IDs		O43395	P78356
PDB IDs		1X4Q 3JCR 5O9Z 6AH0 6AHD 6QW6 6QX9	1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H
Enriched GO Terms of Interacting Partners?
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