PIP4K2B and INO80B

Data Source:
BioGRID (two hybrid)

		PIP4K2B	INO80B
Description		phosphatidylinositol-5-phosphate 4-kinase type 2 beta	INO80 complex subunit B
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Autophagosome Endoplasmic Reticulum Membrane Cytosol Plasma Membrane	Nucleoplasm Nucleolus Ino80 Complex
	Molecular Function	Protein Binding ATP Binding GTP Binding 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidylinositol-5-phosphate 4-kinase Activity Protein Homodimerization Activity	Protein Binding Metal Ion Binding
	Biological Process	Phospholipid Metabolic Process Phosphatidylinositol Biosynthetic Process Cell Surface Receptor Signaling Pathway Regulation Of Autophagy Regulation Of Phosphatidylinositol 3-kinase Signaling Negative Regulation Of Insulin Receptor Signaling Pathway Phosphatidylinositol Phosphorylation Autophagosome-lysosome Fusion Negative Regulation Of 1-phosphatidylinositol-4-phosphate 5-kinase Activity 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate Biosynthetic Process Positive Regulation Of Autophagosome Assembly	DNA Repair DNA Recombination Protein Deubiquitination ATP-dependent Chromatin Remodeling
Pathways		Synthesis of PIPs at the plasma membrane PI5P Regulates TP53 Acetylation PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Synthesis of PIPs in the nucleus	UCH proteinases DNA Damage Recognition in GG-NER
Drugs		Fostamatinib
Diseases
GWAS		Height ( 28552196 20881960 31562340)
Interacting Genes		17 interacting genes: BTK CDCA7L CLK1 CSNK2A1 HMBOX1 HSPB7 INO80B KYNU MLH1 PRPF3 PSMB1 RPRD1B TNFRSF1A TRIM55 TRIM63 UBQLN4 ZNF131	64 interacting genes: ABI2 BANP BHLHB9 BOLL CARD9 CAVIN1 CCDC85B CD81 CDR2L CEP70 CSNK2B CYSRT1 DPPA4 DVL3 E2F6 FLACC1 GOLGA6L9 HMBOX1 HMGXB4 HOMEZ HOXA1 HSF2BP IGFBP2 KCTD7 KRT34 KRT40 KRTAP10-8 KRTAP12-2 KRTAP19-1 KRTAP6-2 LHX4 LIMS1 LZTS2 MID2 MKRN3 MORN3 MTUS2 MYLIP NBPF19 NOTCH2NLA PICK1 PIP4K2B PLAGL2 PNMA1 PNMA2 RBM39 RIMBP3C SOX13 SSX2IP STAC3 THAP1 TLE5 TNS2 TRAF2 TRIB3 TRIM27 TSPYL2 U2AF2 UIMC1 USH1G YAF2 ZNF526 ZNF552 ZRANB1
Entrez ID		8396	83444
HPRD ID		04463	17110
Ensembl ID		ENSG00000276293	ENSG00000115274
Uniprot IDs		P78356	Q9C086
PDB IDs		1BO1 3WZZ 3X01 3X02 3X03 3X04 3X05 3X06 3X07 3X08 3X09 3X0A 3X0B 3X0C 6K4G 6K4H	6HTS
Enriched GO Terms of Interacting Partners?
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